外阴阴道念珠菌定植与感染机制的研究进展

外阴阴道念珠菌病(VVC)是一种由念珠菌引起的女性外阴阴道真菌感染,影响女性的生活质量。VVC的发展通常是由于生理或非生理变化对念珠菌阴道定植与宿主环境稳态的干扰所致。阴道念珠菌定植是绝经前妇女常见情况,念珠菌潜在的致病性及其可能演变为感染的情况还未完全清楚。而一些与宿主和行为相关的危险因素被认为是VVC的诱发因素。对于大多女性而言,念珠菌只是定植在阴道并不引起临床症状时,有些是不需要治疗干预的。但是念珠菌的共生性和VVC间的区别通常是复杂的。本文广泛回顾有关阴道念珠菌定植、致病机制和引起感染的危险因素相关文献,为临床提供有利于改进VVC的预防工作以及新的治疗思路。

Research progress on colonization and infection mechanism of candida vulvovaginalis

Vulvovaginal candidiasis(VVC) is a female vulvovaginal fungal infection caused by candida, which affects the quality of life of many women. VVC development is usually due to the interference of physiological or non-physiological changes with candida vaginal colonization and host environmental homeostasis. Candida vaginalis colonization is common in premenopausal women, and the potential pathogenicity of Candida and its possible evolution into infection is not fully understood. And some risk factors related to host and behavior are considered to be VVC inducing factors. For most women, Candida is only colonized in the vagina but does not cause clinical symptoms, and some do not require therapeutic intervention. But the difference between symbiosis and VVC is often complex. The article reviews the literature on Candida vaginalis colonization,pathogenesis and risk factors for infection to improve the prevention of VVC and new treatment ideas.