A practical access to new pyrrolizine carboxylates via KHMDS-catalyzed carbocyclizations |
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| Authors: | Muhammet Yildirim Garba Suleiman |
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| Affiliation: | 1. Department of Chemistry, Bolu Abant ?zzet Baysal University, Bolu, Turkey;2. Department of Chemistry, Yobe State University, Damaturu, Yobe State, Nigeria |
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| Abstract: | Easy and effective preparation of new 1H-pyrrolizine carboxylates was achieved with high efficiency via KHMDS-induced carbocyclization of N-alkynyl proline carboxylates under substantially mild conditions. Meanwhile, some trans-diiodoallylic N-proline carboxylates were obtained from N-propargyl proline carboxylates using molecular I2 with or without KHMDS. This method is quite feasible in terms of practical and quick access to the pyrrolizines and their derivatives over the formation of carbanions. |
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| Keywords: | 5-endo-dig A3-coupling carbocyclization L-proline" target="_blank">L-proline sonogashira coupling |
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