参香养胃胶囊的抗溃疡药效学研究

目的:研究参香养胃胶囊抗SD大鼠胃溃疡及抗胃黏膜损伤的作用。方法:采用水浸应激法、幽门结扎法、利血平法、醋酸等方法致大鼠胃溃疡,盐酸-乙醇、吲哚美辛致大鼠急性胃黏膜损伤,进行抗胃溃疡和胃黏膜保护实验。结果:参香养胃胶囊能明显抑制水浸应激、幽门结扎、利血平以及醋酸致大鼠胃溃疡;并对盐酸-乙醇、消炎痛所致大鼠急性胃黏膜损伤有明显的抑制作用;结论:参香养胃胶囊具有抗溃疡的作用。

Study on Pharmacodynamics of Shenxiang Yangwei Capsule on Anti-gastric Ulcer

Objective:To study on the effect of Shenxiang Yangwei Capsule(SYC) in inhibiting experimental gastric ulcer and the damage of gastric mucosa in SD rats. Method:The rat gastric ulcer models was induced by water immersing stress method, ligation of pylorus, ip injection of reserpine and acetic acid (HAC) -induced chronic gastric ulcer, and rat models with acute damage of gastric mucosa were induced by hydrochloric acid-ethanol(HAE) and indomethacin. Then the effect of SYC in inhibiting experimental gastric ulcer and the acute damage of gastric mucosa in SD rats were observed. Result:SYC can markedly inhibit the stress gastric ulcer, ligation of pylorus gastric ulcer, reserpjne-induced and HAC-induced gastric ulcer, and then SYC also markedly inhibit influence on HAE-induced and indomethacin-induced acute damage of gastric mucosa in SD rats. Conclusion:SYC possesses counteraction on gastric ulcer.