| 炎症介质对离体大鼠肠系膜动脉降钙素基因相关肽释放的影响 |
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| 引用本文： | 吴中欣,唐跃明,韩启德,王宪.炎症介质对离体大鼠肠系膜动脉降钙素基因相关肽释放的影响[J].生理学报,1996(6). |
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| 作者姓名： | 吴中欣 唐跃明 韩启德 王宪 |
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| 作者单位： | 北京医科大学第三临床医学院血管医学研究所 |
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| 摘 要： | 本工作目的是在离体大鼠肠系膜动脉床灌流模型上，观察几种常见炎症介质：前列腺素Ｅ２（ＰＧＥ２）、缓激肽（ＢＫ）、组胺（ＨＩＳ）、血小板活化因子（ＰＡＦ）及５－羟色胺（５－ＨＴ）对血管周围感觉神经介质ＣＧＲＰ释放的直接影响。结果显示：ＰＧＥ２（１－１００μｍｏｌ／Ｌ）和ＢＫ（５－１０μｍｏｌ／Ｌ）能引起大鼠肠系膜动脉床时间和浓度依赖性地释放ＣＧＲＰ。ＨＩＳ，ＰＡＦ和５－ＨＴ则未见明显作用。结果提示，ＰＧＥ２与ＢＫ可能是引起血管周围感觉神经兴奋和ＣＧＲＰ释放的主要炎症介质。
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| 关 键 词： | 降钙素基因相关肽，炎症介质，肠系膜动脉，感觉神经 |
EFFECTS OF INFLAMMATORY MEDIATORS ON THE RELEASE OF CGRP FROM ISOLATED MESENTERIC ARTERIAL BED OF RAT |
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| WU ZHONG-XIN, TANG YUE-MING, HAN QI-DE, AND WANG XIAN.EFFECTS OF INFLAMMATORY MEDIATORS ON THE RELEASE OF CGRP FROM ISOLATED MESENTERIC ARTERIAL BED OF RAT[J].Acta Physiologica Sinica,1996(6). |
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| Authors: | WU ZHONG-XIN TANG YUE-MING HAN QI-DE AND WANG XIAN |
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| Abstract: | The purpose of the present study was to observe whether inflammatory mediators,such as: Prostaglandin E2 (PGE2), Bradykinin (BK), Histamine (HIS), Platelet activefactor (PAF) and 5-hydroxytryptamine (5-HT), directly triggered the release ofCGRP from perivascular nerves in isolated rat mesenteric arterial bed. The resultsshowed that PGE2 (1-100 umol/L) and BK (5-10 umol/L) caused time- and conceniration-dependent CGRP release, but HIS, PAF and 5-HT did not show significant effeets. Our data indicate that PGE2 and BK are the major inflammatory mediators in triggering the release of CGRP from the perivascular CGRP-containing nerve. |
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| Keywords: | calcitonin gene- related peptide inflammatory mediator mesenteric artery sensory nerve |
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