盐酸小檗碱对急性缺血性脑卒中患者神经功能及血清丙二醛的影响

目的探讨盐酸小檗碱对急性缺血性脑卒中患者神经功能及血清丙二醛（malondialdehyde， MDA）的影响。方法将102例急性缺血性脑卒中患者随机分为盐酸小檗碱组52例和对照组50例。对照组给予改善循环、营养神经、抗血小板聚集及调脂等基础治疗；盐酸小檗碱组在对照组治疗基础上加用盐酸小檗碱片0.5 g，每日3次，连续应用14 天。均在入院治疗前和治疗后7天、14 天抽取卧位静脉血，采用酶联免疫吸附测定法检测血清中MDA的水平；均在入院治疗前和治疗后7天、14 天采用美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale，NIHSS)进行神经功能缺损评分。结果治疗后小檗碱组及对照组NIHSS评分及血清MDA较治疗前均有下降，但小檗碱组NIHSS评分及MDA均低于对照组（P<0.05）。结论盐酸小檗碱可以降低急性缺血性脑卒中降低MDA表达水平，改善神经功能缺损程度。

Effect of berberine hydrochloride on neurological function and serum malondialdehyde in patients with acute ischemic stroke

ObjectiveTo explore the effect of berberine hydrochloride on neuralogical function and serum malondialdehyde (MDA) in patients with acute ischemic stroke. MethodsA total of 102 patients with acute ischemic stroke were randomly divided into two groups， including berberine group 52 cases and control group 50 cases. The control group received routine treatment while berberine group was given berberine hydrochloride 0.5 g three times a day on the basis of routine treatment for 14 days.Blood was collected from both groups before treatment and after treatment of 7 days and 14 days， then the serum MDA was determined with enzyme linked immunosorbent assay. Before treatment and after treatment of 7 days and 14 days， the neural function defect scale was scored by the US National Institutes of Health Stroke Scale (NIHSS). ResultsAfter treatment， the NIHSS score and MDA declined in both groups， and was significantly lower in berberine group than in control group (P<0.05). ConclusionBerberine hydrochloride significantly reduced MDA level in patients with acute ischemic stroke，the drug can improve the degree of neurological function deficit.