| 子宫腺癌患者血清CA125及内膜p16、survivin蛋白的表达及临床意义 |
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| 引用本文： | 徐行丽,井甜甜,黄婷.子宫腺癌患者血清CA125及内膜p16、survivin蛋白的表达及临床意义[J].山东医药,2010,50(13):25-27. |
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| 作者姓名： | 徐行丽 井甜甜 黄婷 |
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| 作者单位： | 滕州市中心人民医院,山东滕州,277500 |
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| 基金项目： | 枣庄市科技发展计划项目 |
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| 摘 要： | 目的探讨血清CA125、组织蛋白p16及survivin在子宫内膜腺癌中的表达及临床意义。方法检测正常子宫内膜组、子宫内膜不典型增生组及子宫内膜腺癌组各40例患者的血清CA125水平及组织中p16及sureivin蛋白的阳性表达情况。结果子宫内膜腺癌组血清CA125水平在手术前后均明显高于其余两组（P均〈0．05）；p16蛋白在子宫内膜腺癌组的表达明显降低，与其余两组比较差异均有统计学意义（P均〈0．05）；survivin蛋白在不典型增生组和子宫内膜腺癌组的阳性表达率及强阳性表达率与正常内膜组相比差异有统计学意义（P均〈0．05）。随着手术病理分期的增高，子宫内膜腺癌患者血清CA125的阳性表达率与survivin的强阳性表达率也明显增高，而p16的阳性表达明显降低。结论血清CA125水平、p16及survivin蛋白对子宫内膜腺癌的手术病理分期及临床预后判断均有重要意义
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| 关 键 词： | CA125 p16蛋白 survivin蛋白 子宫内膜肿瘤 |
Expression of CA125 in serum and p16,survivin protein in endomembrane of endometrial adenocarcinoma patients and its significance |
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| XU Xing-li,JING Tian-tian,HUANG Ting.Expression of CA125 in serum and p16,survivin protein in endomembrane of endometrial adenocarcinoma patients and its significance[J].Shandong Medical Journal,2010,50(13):25-27. |
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| Authors: | XU Xing-li JING Tian-tian HUANG Ting |
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| Affiliation: | XU Xing-li,JING Tian-tian,HUANG Ting(Tengzhou Central People\'s Hospital,Tengzhou 277500,P.R.China) |
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| Abstract: | Objective To study CA125 level of serum and the expression of tissue protein p16 and survivin in endometrial adenocarcinoma and its significance.Methods A total of 120 patients was divided into three groups: the normal endometrium group(40 cases),atypical endometrial hyperplasia group(40 cases) and endometrial cancer group(40 cases).The serum level of CA125 and the expression of p16 and survivin protein in three groups were detected.Results The serum levels of CA125 in endometrial adenocarcinoma group befor... |
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| Keywords: | CA125 |
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