Ovarian autoimmunity and corticotherapy in an in-vitro fertilization attempt

This case report describes a successful pregnancy and deliveryin a woman presenting with ovarian autoimmunity who had previouslybeen involved in two unsuccessful in-vitro fertilization (IVF)attempts. Ten days before a third attempt, she began a regimenof 25 mg per day of prednisolone which was continued throughoutthe whole IVF protocol. Ovulation was induced by human menopausalgonadotrophin. After administration of 5000 IU of human chorionicgonadotrophin, 18 oocytes were collected. At 48 h after inseminationwith the patient's husband's spermatozoa, four 4-cell pre-embryoswere transferred. A singleton pregnancy developed and led tothe birth of a girl who is doing well 10 months later.