基于钯铜催化合成靛红类化合物的新方法

发展了一种合成靛红的新方法, 并进行了底物扩展, 得到了一系列靛红类化合物. 以N-烷基取代的丙烯酰苯胺类化合物为原料, 在醋酸钯、 碘化亚铜和氧气的催化及参与下, 以42%~87%的产率合成了N-烷基化的靛红衍生物. 利用该方法制备了23个靛红类化合物, 并提出了可能的反应机理. 该合成路线减少了保护基的使用, 简洁高效.

Novel Approach to Isatins via Pd-Cu Catalyzed Oxidative Transformation

A new method of synthesizing isatin was developed and applied to the substrate extension to get a series of isatin compounds. Using N-alkyl substituted acrylanilide compounds as raw materials， in palladium acetate， cuprous iodide and under the catalysis and participation of oxygen， N-alkylated isatin derivatives could be synthesized with the yields of 42%—87%. Using this method， 23 isatin compounds were prepared and the possible reaction mechanism was proposed. This synthetic route reduces the use of protecting groups and is simple and efficient.