MicroRNAs as biomarkers and prospective therapeutic targets in colon and pancreatic cancers |
| |
| Authors: | Ganji Purnachandra Nagaraju Appiya Santharam Madanraj Sheik Aliya Balney Rajitha Olatunji Boladale Alese Ekamber Kariali Afroz Alam Bassel F El-Rayes |
| |
| Affiliation: | 1.Department of Hematology and Medical Oncology, Winship Cancer Institute,Emory University,Atlanta,USA;2.Department of Infection, Immunity and Inflammation,University of Leicester,Leicester,UK;3.Department of Biotechnology,Jawaharlal Nehru Technological University,Hyderabad,India;4.Department of Microbiology,Banasthali University,Banasthali,India;5.School of Life Sciences, Department of Biotechnology,Sambalpur University, Jyoti Vihar,Sambalpur,India |
| |
| Abstract: | Colon and pancreatic cancers have high mortality rates due to early metastasis prior to the onset of symptoms. Screening tests for colorectal cancer are invasive and expensive. No effective screening is available for pancreatic cancer. Identification of biomarkers for early detection in both of these cancers is being extensively researched. MicroRNAs (miRNA) are small non-coding molecule biomarkers that regulate cancers. Measurement of miRNAs in pancreatic fluid or blood could be a preferred non-invasive screening method. The regulation of colon and pancreatic cancers by miRNA is complex. miRNA play a central role in inflammation, invasiveness, and tumor progression in these two cancers, as well as regulation of the NF-κB pathway. miRNA’s evolving role in screening is also reviewed. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
