从胰岛素敏感性和胰岛β细胞功能看空腹血糖受损切点下调 |
| |
引用本文: | 张丽红,许岭翎,向红丁,黎明,李乃适,平凡,陈伟,方京徽. 从胰岛素敏感性和胰岛β细胞功能看空腹血糖受损切点下调[J]. 中华糖尿病杂志, 2008, 16(9): 515-517 |
| |
作者姓名: | 张丽红 许岭翎 向红丁 黎明 李乃适 平凡 陈伟 方京徽 |
| |
作者单位: | [1]北京协和医院内分泌科,100730 [2]北京协和医院内营养科,100730 |
| |
摘 要: | 目的评估空腹血糖正常(NFG)人群胰岛素敏感性(IS)和胰岛β细胞功能的特点。方法2388例受试者按OGTT结果分为低-空腹血糖正常(Low-NFG)组(FPG〈4.9mmol/L),中-空腹血糖正常(Mid-NFG)组(FPG4.9~5.6mmol/L),高-空腹血糖正常(High-NFG)组(FPG5.6~6.1mmol/L),IFG组,T2DM组。利用OGTT推导出几个指数比较各组IS和胰岛素分泌差别。结果从Low-NFG到T2DM组,β细胞分泌功能和胰岛素敏感性指数进行性下降。与Mid-NFG组比较,High-NFG组胰岛素抵抗更加明显,胰岛素分泌下降,TG升高和HDL-C降低(P〈0.01)。结论FPG5.6~6.1mmol/L时存在高胰岛素抵抗和低胰岛β细胞功能,是T2DM的高危因素。
|
关 键 词: | 空腹血糖受损 胰岛素敏感性 胰岛β细胞功能 |
The clinical significance of lowering the cut-point of impaired fasting glucose: in view of insulin sensitivity and islet β cell function |
| |
Affiliation: | ZHANG Li-hong, XU Ling-ling, XIANG Hong ding, et al.(Department of Endocrinology, PUMC Hospital ,CAMS and PUMC ,Beijing 100730, China) |
| |
Abstract: | Objective To evaluate the features of insulin sensitivity and β-cell function in a Chinese population with normal fasting glucose. Methods 2,388 subjects aged≥20 years were divided into 5 groups based on the results of oral 75-g glucose tolerance test(OGTT) : low-NFG,mid-NFG,high-NFG, IFG,T2DM. We compared insulin secretion and insulin sensitivity using several indexes derived from OGTT. Results There was a progressive decline in indexes of β-cell function and insulin sensitivity when moving from NFG to type 2 diabetes. Compared with subjects with mid-NFG (FPG 4.9-5.6mmol/ 1), subjects with high-NFG (FPG5.6-6.1 mmol/l)were more resistant to insulin, and had reduced insulin secretion, higher plasma triglyceride level and reduced HDL cholesterol concentrations (P 〈 0.01- 0. 001). Conclusion Subjects with FPG 5.6-6.1 mmol/l may predispose to type 2 diabetes. |
| |
Keywords: | Impaired fasting glucose Insulin sensitivity Islet β-cell function |
本文献已被 维普 万方数据 等数据库收录! |
|