| 药物对缺氧细胞内钙离子浓度的影响 |
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| 引用本文： | 廖贤平 佘亚雄. 药物对缺氧细胞内钙离子浓度的影响[J]. 武警医学, 1999, 10(8): 438-439 |
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| 作者姓名： | 廖贤平 佘亚雄 |
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| 作者单位： | 武警广东总队医院三外科!广州510507(廖贤平)，上海第二医科大学新华医院(佘亚雄，李敏) |
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| 摘 要： | 目的 比较三磷酸腺苷（ Ａ Ｔ Ｐ） 、三磷酸腺苷－ 氯化镁（ Ａ Ｍ） 、异搏停（ Ｖ Ｅ Ｒ） 和超氧化物歧化酶（ Ｓ Ｏ Ｄ） 防止细胞 Ｈ／ Ｒ 损伤时４５ Ｃａ 内流的效果。方法 应用人类小肠上皮细胞缺氧－ 再给氧（ Ｈ／ Ｒ） 模型及同位素示踪方法。结果 Ａ Ｔ Ｐ、 Ａ Ｍ、 Ｖ Ｅ Ｒ 和 Ｓ Ｏ Ｄ 均可显著减少４５ Ｃａ 内流量，前３ 组细胞内４５ Ｃａ 含量低于 Ｓ Ｏ Ｄ 组。结论 Ａ Ｔ Ｐ、 Ａ Ｍ、 Ｖ Ｅ Ｒ 和 Ｓ Ｏ Ｄ 均具有维持细胞钙稳态作用， Ｓ Ｏ Ｄ 效果逊于其它３ 组药物。
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| 关 键 词： | 上皮细胞 缺氧 钙稳态 药物保护 |
Comparison of several drugs in maintaining calcium homeostasis in hypoxic cells |
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| Liao Xianping,She Yaxiong and Li Ming. Comparison of several drugs in maintaining calcium homeostasis in hypoxic cells[J]. Medical Journal of the Chinese People's Armed Police Forces, 1999, 10(8): 438-439 |
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| Authors: | Liao Xianping She Yaxiong Li Ming |
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| Affiliation: | Liao Xianping,She Yaxiong and Li Ming.Department of Urology,Guangdong Provincial Corps Hospital,Chinese People's Armed Police Forces,Guangzhou 510507,China |
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| Abstract: | Objective To compare the effects of adenosine friphosphate (ATP),ATP-MgCl 2(AM),verapamil(VER),and superoxiedismutase (SOD)in prevention of influx of 45 Ca.Methods The model of hypoxia and reoxygenation(H/R)in fetal intestinal epithelial cells (IEC) and the method of isotope tracer were used.Results ATP,AM,VER and SOD conld significantly reduce the amount of intracellular 45 Ca,although 45 Ca uptake in SOD group was much higher than in the other treated groups.Conclusion ATP,AM,VER and SOD all can in maintain calcirm homeostasis in hypoxic cells.However,SOD is less effective than other agents in prevention of calcium overload in cell H/R. |
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| Keywords: | Epithelial cells Hypoxia Calium homeostasis Drug Prevention |
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