| A1核内注射神经肽Y对猫血压和血浆内儿茶酚胺的影响 |
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| 引用本文： | 杨绍年,唐毓环.A1核内注射神经肽Y对猫血压和血浆内儿茶酚胺的影响[J].中国药理学报,1992,13(5):400-402. |
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| 作者姓名： | 杨绍年 唐毓环 |
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| 摘 要： |
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| 关 键 词： | 神经肽Y 血压 儿茶酚胺 |
Effects of neuropeptide Y injected into A1 noradrenergic nucleus on blood pressure and catecholamines in plasma of cats. |
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| S N Yang,Y H Tang,X L Yang,S Wang.Effects of neuropeptide Y injected into A1 noradrenergic nucleus on blood pressure and catecholamines in plasma of cats.[J].Acta Pharmacologica Sinica,1992,13(5):400-402. |
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| Authors: | S N Yang Y H Tang X L Yang S Wang |
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| Affiliation: | Department of Physiology, Norman Bethune University of Medical Sciences, Changchun, China. |
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| Abstract: | The microinjection of neuropeptide Y (NPY) 0.75 and 1.5 micrograms into A1 noradrenergic nucleus of cats produced dose-dependent falls in mean arterial blood pressure of 2.0 +/- 0.6 and 4.9 +/- 2.4 kPa, respectively. NPY microinjection (1.5 micrograms) also produced marked decreases in noradrenaline (5 +/- 4 pmol.ml-1) and adrenaline (23 +/- 8 pmol.ml-1), but no significant change in dopamine in blood plasma. The results suggest that the depressor effect of NPY in A1 noradrenergic nucleus may be realized by not only reducing the release of noradrenaline in sympathetic terminals around the peripheral vascular beds but also inhibiting the sympathetico-adrenal system. |
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