阿苯达唑对小鼠旋毛虫囊包幼虫作用后的组织化学观察

目的：探讨阿苯达唑对小鼠旋毛虫囊包幼虫的作用机制。方法：应用形态学、组织学及组织化学方法观察阿苯达唑治疗后囊包幼虫的形态学、组织学及酶的活性变化。结果：阿苯达唑治疗组，囊包幼虫的结构明显破坏，虫体缩小与断裂，部分虫体被吸收，囊包内伴有炎细胞浸润。组织化学染色显示，治疗组虫体糖原减少， Ｒ Ｎ Ａ、 Ｓ Ｄ Ｈ、 Ａ Ｔ Ｐａｓｅ、 Ａ Ｃ Ｐ活性均低于对照组，而 Ｌ Ｄ Ｈ 活性高于对照组。结论：阿苯达唑对旋毛虫的生理功能有影响。

MORPHOLGICAL,HISTOLOGICAL AND HISTOCHEMICAL OBSERVATIONS ON THE EFFECT OF ALBENDAZOLE ON ENCYSTED LARVAE OF TRICHINELLA SPIRALIS IN MICE

AIM: To study the mechanism of action of albendazole on encysted larvae of Trichinella spiralis in mice. METHODS: Twelve Kunming strain mice each infected with 200 T. spiralis larvae were equally divided into two groups. Six mice of the treatment group were treated with 30 mg of albendazole/kg daily for 5 days. Morphological, histological and histochemical methods were used. RESULTS: The encysted larvae of albendazole treated group became significantly damaged,most worms were shrunken and surrounded by inflammatory cells.Histochemical study demonstrated that the glycogen and RNA content of the larvae in the treated group was decreased,the activities of SDH,ATPase, ACP were lower than those of the control group. CONCLUSION: Albendazole can affect the physiological function of Trichinella spiralis .