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Alleviation of Liver Dysfunction,Oxidative Stress,and Inflammation Underlines the Protective Effects of Polysaccharides from Cordyceps cicadae on High Sugar/High Fat Diet-Induced Metabolic Syndrome in Rats |
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| Authors: | Xiao Zhang Jinpeng Li Bo Yang Qina Leng Ji Li Xintuan Wang Junyao Lu Opeyemi Joshua Olatunji Jian Tang |
| Affiliation: | 1. Department of Medical Cosmetology, Linyi Central Hospital, Linyi, 276400 P. R. China
These two authors contributed equally to this work (co-first authors).;2. Interventional Therapy Department Ward 1, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117 P. R. China These two authors contributed equally to this work (co-first authors).;3. Department of Emergency, The People's Hospital of Zhaoyuan City, Zhaoyuan, 265400 P. R. China;4. Urinary Surgery, The People's Hospital of Zhaoyuan City, Zhaoyuan, 265400 P. R. China;5. Department of Hepatobiliary Surgery, People's Hospital of Hechuan, Chongqing, 401520 P. R. China;6. Department of Hepatobiliary Surgery, The First People's Hospital of Xianyang, Xianyang, 712000 P. R. China;7. Department of Infectious Disease, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201900 P. R. China;8. Faculty of Thai Traditional Medicine, Prince of Songkla University, Hat Yai, 90110 Thailand;9. School of Chinese Medicine, Bozhou University, Bozhou, 236800 P. R. China |
| Abstract: | This study investigated the protective effects of two polysaccharides (CPA-1 and CPB-2) from Cordyceps cicadae against high fructose/high fat diet (HF/HFD) induced obesity and metabolic disorders in rats. Rats were either fed with normal diet or HF/HFD and treated with CPA-1 and CPB-2 (100 and 300 mg/kg) for 11 weeks. Administration of CPA-1 and CPB-2 significantly and dose dependently reduced body and liver weight, insulin and glucose tolerance, serum insulin and glucose levels. Furthermore, serum and hepatic lipid profiles, liver function enzymes and proinflammatory cytokines (TNF-α, IL-1β and IL-6) were markedly reduced. Additionally, CPA-1 and CPB-2 treatment alleviated hepatic oxidative stress by reducing lipid peroxidation level (MDA) and upregulating glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) activities as well as ameliorated histological alterations through the reduction of hepatic lipid accumulation. These results suggested that the polysaccharides from C. cicadae showed protective effects against HF/HFD induced metabolic disturbances and may be considered as a dietary supplement for treating obesity. |
| Keywords: | Cordyceps cicadae polysaccharide anti-obesity effect insulin resistance oxidative stress |
