胃癌组织ＥＧＦＲ和ＣＯＸ-２的表达与幽门螺杆菌感染关系

目的:探讨表皮生长因子受体(EGFR)、环氧化酶-2(COX-2)在胃癌组织中的表达及其相关性,并探究它们与幽门螺杆菌(H.pylori)感染的关系.方法:采用免疫组化EnVision两步法检测47例胃癌组织及相应的20例癌旁组织EGFR、COX-2的表达;用快速尿素酶诊断法和13C呼气试验两种方法检测胃癌患者H.pyliri感染状况.结果:胃癌组织中EGFR、COX-2的阳性表达率均明显高于癌旁组织(P＜0.01);EGFR、COX-2在胃癌中表达呈正相关(P＜0.05).有H.pylori感染的胃癌组织中EGFR、COX-2的阳性表达率较未感染的胃癌组织中高(P＜0.01).结论:EGFR、COX-2在胃癌组织中高表达且有相关性;H.pylori感染可能上调胃癌组织中EGFR、COX-2的表达.

Expression EGFR and COX-2 in human gastric carcinoma and their relationship with H.pylori infection

Objective:To investigate the expression of EGFR and COX-2 and their correlations in human gastric carcinoma,and analyze their relationship with H.pylori infection. Methods:By Immunochemical EnVision method,the expression of EGFR and COX-2 were detected in 47 cases of gastric cancer and 20 cases of cancer-adjacent tissues. The statuses of H.pylori infection were detected by fast urea enzyme test and 13C breath test. Results:The positive rates of EGFR and COX-2 in gastric carcinoma were significantly higher than those in paraneoplastic tissues(P<0.01). There were significantly positive correlation between the expression of EGFR,COX-2(P<0.05),and the expression with H.pylori infection were higher than those without H.pylori infection(P<0.01). Conclusion:EGFR and COX-2 were overexpressed in gastric carcinoma,and there were positive correlations between them. H.pylori infection could upregulate the expression of EGFR and COX-2 in gastric cancer tissues.