| (S)-酮基布洛芬的制备 |
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| 引用本文： | 刘志雄,李翔. (S)-酮基布洛芬的制备[J]. 精细化工中间体, 2005, 35(3): 24-25 |
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| 作者姓名： | 刘志雄 李翔 |
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| 作者单位： | 湖北省化学研究院,湖北,武汉,430074;湖北省化学研究院,湖北,武汉,430074 |
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| 摘 要： | 以(-)-葡辛胺为拆分剂,研究了(RS)-酮基布洛芬的拆分与(R)-酮基布洛芬的消旋;在异丙醇溶剂中成盐,以KOH碱解S-酮基布洛芬的ee值为99.5%,单轮拆分率达40%.
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| 关 键 词： | S-酮基布洛芬 (-)-葡辛胺 半量拆分 消旋化 |
| 文章编号： | 1009-9212(2005)03-0024-02 |
| 修稿时间： | 2004-12-15 |
Preparation of (S)-Ketoprofen |
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| LIU Zhi-xiong,LI Xiang. Preparation of (S)-Ketoprofen[J]. Fine Chemical Intermediates, 2005, 35(3): 24-25 |
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| Authors: | LIU Zhi-xiong LI Xiang |
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| Abstract: | The resolution of (RS)-Ketoprofen into (S)-Ketoprofen was found to be effective via the N-octyl D-glucamine . The result of this method showed that each resolution yield was 40% with high optical purity of over 99%. Racemization of (R)-Ketoprofen had been studied and gave good results. |
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| Keywords: | (S)- Ketoprofen N-octyl D-glucamine Resolution Racemization |
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