| 3,4-亚甲二氧苯丙烯酸的合成工艺改进 |
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| 引用本文： | 盘鹰,何小英.3,4-亚甲二氧苯丙烯酸的合成工艺改进[J].汕头大学医学院学报,2004,17(3):149-150. |
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| 作者姓名： | 盘鹰 何小英 |
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| 作者单位： | 汕头大学医学院化学教研室,广东,汕头,515041 |
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| 摘 要： | 目的：改进3，4-亚甲二氧苯丙烯酸的合成工艺。方法：以胡椒醛、丙二酸二乙酯为原料，甲苯为溶剂，在醋酸哌啶的催化下，经过缩合、水解、脱羧合成。结果：新方法合成得到的产品化学结构及理化参数与文献相符。结论：改进后的合成方法具有降低原料成本，减少环境污染，适合工业生产等优点。
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| 关 键 词： | 3，4-亚甲二氧苯丙烯酸 合成工艺 药物化学 丙二酸二乙酯 痫灵 |
| 文章编号： | 1007-4716(2004)03-0149-02 |
| 修稿时间： | 2004年4月16日 |
Improvement of the Synthesis of 3,4-Methylenedioxy Phenylpropenoic Acid |
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| PAN Ying,HE Xiao-ying.Improvement of the Synthesis of 3,4-Methylenedioxy Phenylpropenoic Acid[J].Journal of Shantou University Medical College,2004,17(3):149-150. |
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| Authors: | PAN Ying HE Xiao-ying |
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| Abstract: | Objective:To improve the synthesis of 3,4-methylenedioxy phenylpropenoic acid.Methods:Taking 3,4-methylenedioxy benzaldehyde and malonic ester as materials,toluene as solvent,3,4-methylenedioxy phenylpropenoic acid was synthesized by the reactions of condensation,hydrolysis and decarboxylation.Results:The parameters of the product synthesized by new method were coincident with those in literature.Conclusion:The new method can reduce the cost of materials and satisfy the industrial production.Also the pollution of environment is lessened. |
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| Keywords: | Methylenedioxy Phenylpropenoic Acid Malonic Ester Knoevenagel-Doebner Reaction |
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