莆田地区临床常见病原菌分布及耐药性分析

目的了解莆田地区临床病原菌流行分布及对常用抗生素耐药性。方法按《全国临床检验操作规程》培养分离菌种,VATEK 32鉴定仪进行细菌鉴定及药敏感试验。结果2年共检出细菌3230株,其中G-杆菌1652株,占51.1%,以非发酵菌为主;G 球菌1012株,占31.3%;真菌486株,占15.1%。大部分病原菌对常用抗菌素产生多重耐药,产ESBL s的大肠埃希菌和克雷伯菌属检出率分别为38.3%和55.9%,耐苯唑西林的葡萄球菌为68.4%。结论真菌感染和细菌多重耐药性是目前最严重的问题,注意合理使用抗生素,加强对细菌变迁动态及耐药性的全面监测。

Distribution and drug resistance of commonly identified clinical pathogens in Putian

Objective To investigate the distribution and drug resistance of the pathogenic floras isolated from the clinical specimen in Putian.Methods.Flora cultivation and isolation were operated based on the National Clinical Laboratory Operational Regulations.Flora was identified with VITEK-32 automatic identifier,and bacteriostatic test was operated with KIRby-baucer method.Results.A total of 3230 strains were isolate between 2003 and 2004.The proportions of gram-negative bacilli,gram-positive cocci and fugus were 51.1%(1652 strains,most of them were nonfermenters),31.3%(1012 strains) and 15.1%(486 strains) respectively.Most of these pathogens showed multiple drug resistance.The detective rate of E.coli(ESBLs),K.pneumoniae(ESBLs) and oxacillin resistant S.aureus(MRSA) were 38.3%,55.9% and 68.4% respectively.Conclusion. Now the most serious problems are fugus infection and multiple drug resistance.It is important to take note of reasonable application of antibacterials and strengthen surveillance of the vicissitudes trends and resistance of bacteria.