不同来源干细胞移植治疗炎症性肠病

背景：干细胞移植后可迁移至受损肠道参与损伤组织修复和功能重建,并可恢复肠道正常的免疫功能。目的：综述不同来源干细胞移植治疗炎症性肠病的研究进展。方法：应用计算机检索1990/2008 PubMed数据库相关文章,检索词为＂stem cells,tissue engineering,biliary complications,intestinal disease,human intestinal tract＂,并限定文章语言种类为English。同时计算机检索1990/2008万方数据库相关文章,检索词为＂干细胞,组织工程,肠道疾病,人工肠道＂,并限定文章语言种类为中文。最终纳入符合标准的文献24篇。结果与结论：目前炎症性肠病的治疗在于控制活动性炎症和调节免疫紊乱,包括抗炎药物、激素、免疫抑制剂、生物治疗等多种治疗手段,但无一具有长期疗效且不良反应颇多,而近年来干细胞再生、营养、免疫调节等方面的研究给肠性疾病相关治疗带来了新希望,其多向分化潜能、免疫调节作用、营养作用使干细胞移植有望成为肠道疾病治疗的有效途径,干细胞和组织工程在肠道的研究有十分广阔的应用前景。

Transplantation of stem cells from different sources for treatment of inflammatory bowel disease

BACKGROUND： The transplanted stem cells can migrate to injured intestinal tract to participate in injured tissue repair and functional reconstruction and can contribute to recovery of normal immunological function of intestinal tract. OBJECTIVE： To review the research progress in transplantation of stem cells from different sources for treatment of inflammatory bowel disease. METHODS： A computer-based online retrieval of papers published between 1990-2008 were searched in PubMed and Wanfang database using the key words of ＂stem cells, tissue engineering, biliary complications, intestinal disease, human intestinal tract＂ in English and Chinese respectively. Twenty-four papers were included in the final analysis. RESULTS AND CONCLUSION： Treatment of inflammatory bowel disease is mainly to control reactive inflammation and regulate immunologic derangement, involving anti-inflammatory drugs, hormone, immunosuppressant, biological treatment. But all these methods need long term treatment and showed many adverse events. Recently, studies on stern cell regeneration, nutrition and immunoloregulation bring new hope for treatment of intestinal disease. Transplantation of stem cells are hopeful to become an effective mean for treatment of intestinal disease due to their multi-directional differentiation, immunotoregulation and nutrition properties. Stem cells and tissue engineering show a wide application prospect in treatment of intestinal diseases.