青少年广泛性焦虑障碍患者静息态功能磁共振成像研究

目的:运用局部一致性(ReHo)方法研究首发青少年广泛性焦虑障碍患者的局部自发性脑活动. 方法:对19例首发青少年广泛性焦虑障碍患者及14名年龄、性别与其相匹配的正常对照进行静息态脑功能磁共振成像扫描,通过计算每个给定体素与其最邻近的26个体素之间的肯德尔和谐系数(KCC)来获得全脑的局部一致性(ReHo)图,利用双样本t检验分析两组受试者静息态下局部一致性的差异. 结果:与正常对照相比,青少年广泛性焦虑障碍患者局部一致性降低的脑区包括双侧额中回、枕中回,左侧额上回、颞下回、前扣带回及右侧顶下回、枕下回(P ＜0.005,未校正)；局部一致性增高的脑区包括:右侧楔前叶、角回及左侧枕上回(P ＜0.005,未校正). 结论:青少年广泛性焦虑障碍患者静息态脑功能局部一致性存在异常.

A resting-state fMRI study of adolescents with generalized anxiety disorder

Objective:To investigate regional spontaneous brain activity in adolescents with first-episode generalized anxiety disorder using a method of regional homogeneity (ReHo).Method:19 adolescents with first-episode generalized anxiety disorder (GAD) and 14 normal age-matched healthy volunteers underwent resting-state functional MRI.In the present study,a method was used based on the regional homogeneity (ReHo),in which KCC was used to measure the similarity of the time series of a given voxel to those of its nearest 26 neighbors in a voxel-wise way.Two-sample t test was used to compare regional spontaneous brain activity across whole brain between the two groups.Results:Compared with control group,patients with GAD exhibited decreased ReHo in bilateral middle prefrontal cortex and middle occipital cortex,left superior prefrontal cortex,inferior temporal cortex and anterior cingulate,right inferior occipital cortex and parietal cortex (P<0.005,uncorrected).Patients with GAD also exhibited increased ReHo in right precuneus,angular gyrus and left superior occipital cortex (P<0.005,uncorrected).Conclusion:Abnormal ReHo are detected in adolescents with GAD.