卡维地洛对兔缺血再灌注心律失常和梗死范围的影响

目的探讨卡维地洛对兔缺血再灌注性心律失常和心肌梗死(MI)范围的影响。方法新西兰大白兔50只,随机分为5组,每组10只;Ⅰ组:假手术组,Ⅱ组:急性心肌梗死(AMI)组,Ⅲ组:缺血再灌注组,Ⅳ组:利多卡因组,V组:卡维地洛组。Ⅱ、Ⅲ、Ⅳ、V组分别结扎冠状动脉左室支中点30 min再灌注120 min,观察室性期前收缩(PVC)、室性心动过速(VT)、心室颤动(Vf)的发生率和MI范围的变化。结果应用利多卡因和卡维地洛后,PVC、VT、Vf的发生率显著低于缺血再灌注组,利多卡因和卡维地洛两组之间差异无统计学意义。利多卡因能有效的减少缺血再灌注时心律失常的发生率,但对MI范围无影响,卡维地洛不仅有效的减少缺血再灌注时心律失常的发生率,而且能显著的缩小MI范围。结论卡维地洛能有效的减少缺血再灌注时心律失常的发生,明显缩小MI范围。

Effects of carvedilol on the reduction of arrhythmia incidence and myocardial infarct size in ischemia/reperfusion rabbits

Objective To explore the effects of carvedilol on arrhythmia incidence and myocardial infarct size in ischemia/reperfusion rabbits.Methods Fifty New Zealand white rabbits were randomly divided into five groups(ten for each Group): sham group,GroupⅠ;Acute myocardial infarction group,Group Ⅱ;ischemia/reperfusion group,Group Ⅲ;lidocaine group,Group Ⅳ;carvedilol group,Group V.The middle point of left ventricular coronary artery was ligated(GroupⅡ,Ⅲ,Ⅳ and V) for 30 minutes and reperfused for 120 minutes.The incidences of premature ventricular contraction(PVC),ventricular tachycardia(VT),and ventricular fibrillation(Vf) and myocardial infarct size were observed.Results Compared with ischemia /reperfusion group,carvedilol decreased arrhythmia incidence and myocardial infarct size significantly(P<0.01 respectively),but lidocaine only decreased arrhythmia incidencesignificantly(P<0.01) and had no effect on myocardial infarct size(P>0.05).Conclusions Carvedilol can decrease arrhythmia incidence and myocardial infarct size in ischemia/reperfusion rabbits.