Bcl-2和P53蛋白在胃肠道粘膜相关淋巴组织淋巴瘤中的表达及其临床意义

e目的 通过Ｂｃｌ－２和Ｐ５３蛋白在胃肠道粘膜相关淋巴组织（ＭＡＬＴ）淋巴中的表 达，探讨它们与肿瘤恶性程度及预后的关系。方法 收集我院１９９０年１月到１９９７年１２月胃肠道ＭＡＬＴ淋巴瘤２４例，行常规ＨＥ和ＬＳＡＢ法免疫组化染色，ＤＡＢ染色，苏木素复染。结果 ２４例均为Ｂ细胞ＭＡＬＴ淋巴瘤，属低度恶性１６例（占６６．７％），高度恶生８例（占３３．３％）。Ｂｃｌ－２在低度和高度恶性ＭＡＬＴ淋巴瘤中的

Expression of oncoproteins Bcl-2 and P53 in patients with gast rointestinal mucosa-associated lymphoid tissue lymphoma and their clinical sign ificances

Objective To investigate therelationship of Bcl 2 and P53 expressions to the histologicalgrading and prognosis in patients with gastrointestinal M A L Tlym phoma . Methods 24 cases with gas trointestinal M A L Tlym phom a from 1990 to 1997 in our hospital were studied with H Eand im m unohisto chemicalstaining . Results All cases were B cell M A L Tly mpho mas. Among them 16 cases were of high grade ,8 low grade . Bcl 2 expression was positive in 16 and negative in 8 . P53 expression was positive andnegativein 12 cases each . The Bcl 2 expression varied in M A L Tly mpho ma patients with high and lowgrade maligancy ,the prognosis was also different ,but no difference was found in P53 expression . Conclusion Bcl 2 is usefulin determining the malignant grading of gastrointestinal M A L Tly m pho ma and in predict ing the prognosis while P53 is not .( Shanghai Med J,1999 ,22 :469 471)