艾滋病合并播散性马尔尼菲青霉菌病预后因素分析

目的 探讨影响AIDS合并播散性马尔尼菲青霉菌病(DPsM)预后的因素.方法 应用Logistic回归方法对124例AIDS合并DPsM患者的临床和实验室资料进行回顾性分析,筛选出独立预后因素.结果 124例AIDS合并DPsM患者的病死率为29.84%.单因素分析结果显示,影响AIDS合并DPsM预后的因素包括:血白...

Prognostic Factors of Disseminated Penicilliosis Marneffei in Patients with Acquired Immunodeficiency Syndrome

Objective To explore the prognostic factors of disseminated Penicilliosis Marneffei（DPsM）in patients with acquired immunodeficiency syndrome（AIDS）.Methods 124 cases of AIDS complicated with DPsM were evaluated by logistic regression analysis in order to determine independent prognostic factors.Results 124 cases with a mortality rate of 29.84%.In the univariate analysis,10 variables associated significantly with the prognosis of AIDS complicated with DPsM.These variables included leukocyte count,total bilirubin,the serum albumin level,blood urea nitrogen,creatinine,CD4＋T lymphocyte count,hepatosplenomegaly,drug abuse or excessive drinking,antiretroviral therapy and using of hormone.Multivariate logistic regression analysis showed the increase of BUN（OR=0.584,95%CI 0.369-0.925）was risk factor related to the mortality of AIDS patients with DPsM,meanwhile,CD4＋T lymphocyte count（OR=1.364,95%CI 1.038-1.792）and antiretroviral therapy（OR=17.084,95%CI 5.297-71.668）provided protective effect.Conclusion The increase of BUN is the risk factors contributing to the poor prognosis of AIDS patients with DPsM,while CD4＋T lymphocyte count or antiretroviral therapy can reduce the mortality and improve the prognosis.