Epidural Electrotherapy for Epilepsy |
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| Authors: | Sung‐Won Park Jejung Kim Minpyo Kang Wonho Lee Byong Seo Park Hansung Kim Se‐Young Choi Sungchil Yang Jong‐Hyun Ahn Sunggu Yang |
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| Affiliation: | 1. Department of Nano‐Bioengineering, Incheon National University, Incheon, South Korea;2. School of Electrical & Electronic Engineering, Yonsei University, Seoul, South Korea;3. Department of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong;4. Department of Physiology, Seoul National University School of Dentistry, Seoul, South Korea |
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| Abstract: | Penetrating electronics have been used for treating epilepsy, yet their therapeutic effects are debated largely due to the lack of a large‐scale, real‐time, and safe recording/stimulation. Here, the proposed technology integrates ultrathin epidural electronics into an electrocorticography array, therein simultaneously sampling brain signals in a large area for diagnostic purposes and delivering electrical pulses for treatment. The system is empirically tested to record the ictal‐like activities of the thalamocortical network in vitro and in vivo using the epidural electronics. Also, it is newly demonstrated that the electronics selectively diminish epileptiform activities, but not normal signal transduction, in live animals. It is proposed that this technology heralds a new generation of diagnostic and therapeutic brain–machine interfaces. Such an electronic system can be applicable for several brain diseases such as tinnitus, Parkinson's disease, Huntington's disease, depression, and schizophrenia. |
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| Keywords: | epidural electronics epilepsy graphene thalamocortical network therapeutic devices |
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