| 5-氨基苯[b]并噻吩-2-甲酸乙酯的合成 |
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| 引用本文： | 张少宁,魏红涛,吉民.5-氨基苯[b]并噻吩-2-甲酸乙酯的合成[J].化工时刊,2010,24(3):4-5. |
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| 作者姓名： | 张少宁 魏红涛 吉民 |
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| 作者单位： | 东南大学化学化工学院制药工程系,江苏,南京,210096 |
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| 摘 要： | 以2-氯-5-硝基苯甲醛为原料,与巯基乙酸乙酯发生环合,得到5-硝基苯b]并噻吩-2-甲酸乙酯,再在Pd/C和甲酸铵作用下,经过氢化还原得到5-氨基苯b]并噻吩-2-甲酸乙酯,总产率89.4%。
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| 关 键 词： | 2-氯-5-硝基苯甲醛 环合 还原 |
Synthesis of Ethyl 5-aminobenzo[b]thiophene-2-carboxylate |
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| Zhang Shaoning,Wei Hongtao,Ji Min.Synthesis of Ethyl 5-aminobenzo[b]thiophene-2-carboxylate[J].Chemical Industry Times,2010,24(3):4-5. |
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| Authors: | Zhang Shaoning Wei Hongtao Ji Min |
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| Affiliation: | Zhang Shaoning Wei Hongtao Ji Min(Department of Pharmaceutical Engineering,School of Chemistry ＆ Chemical Engineering,Southeast University,Jiangsu Nanjing 210096) |
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| Abstract: | With 2-chloro-5-nitrobenzaldehyde reducted with ethyl 2-mercaptoacetate,the ethyl 5-nitrobenzob]thiophene-2-carboxylate was produced.Then in the presence of Pd/C and ammonium formate,ethyl 5-aminobenzob]thiophene-2-carboxylate was synthesized by reduction with overall yield of 89.4%. |
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| Keywords: | 2-chloro-5-nitrobenzaldehyde cyclization reduction |
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