高血压患者糖代谢异常与脂联素和颈动脉粥样硬化关系的观察

目的 探讨原发性高血压患者糖代谢异常与APN及颈动脉粥样硬化的关系. 方法 纳入150例原发性高血压患者,根据FPG和75 gOGTT检测结果分为糖耐量正常（NGT）组、IGT组和DM组.ELISA检测3组血清APN水平,彩色多普勒超声检测颈动脉内膜-中层厚度（IMT）及粥样斑块,并进行比较. 结果 3组间APN、IMT比较,差异均有统计学意义（P＜0.05）.APN与SBP、DBP、FPG、2 hPG、IMT呈负相关.多元逐步回归分析显示SBP、2 hPG是影响APN水平的独立因素. 结论 原发性高血压患者合并不同程度糖代谢异常,其严重程度与血清APN、IMT相关.

Relationship of abnormal glucose metabolism with carotid artery atherosclerosis and adiponectin in patients with essential hypertension

Objective To investigate the relationship of the abnormal glucose metabolism with carotid artery atherosclerosis and adiponectin （APN） in patients with essential hypertension.Methods Based on the levels of FPG and 2 hPG,the 150 patients with essential hypertension were divided into 3 groups：normal glucose tolerance （NGT） group,impaired glucose tolerance （IGT） group,and diabetes mellitus （DM） group.The APN and carotid artery intima-media thickness （IMT） in the three groups were determined for comparison.Results The difference in APN and IMT among the three groups was statistically significant （P＜0.05）.The APN level was negatively correlated with SBP,DBP,2 hPG,FPG and IMT.Multiple stepwise regression analysis showed that SBP and 2 hPG were the independent factors influencing APN.Conclusion The severity of abnormal glucose metabolism in patients with essential hypertension is closely related to serum APN and IMT.