Gd-DTPA-cascade-polymer: Potential blood pool contrast agent for MR imaging |
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Authors: | Gerhard Adam Jrg Neuerburg Elmar Spüntrup Andreas Mühler Kira Scherer Vet Surg Rolf W Günther |
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Affiliation: | Gerhard Adam,Jörg Neuerburg,Elmar Spüntrup,Andreas Mühler,Kira Scherer Vet Surg,Rolf W. Günther |
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Abstract: | Gadolinium-DTPA (diethylenetriaminepentaacetic acid)-cascade-polymer, a potential new blood pool contrast agent for magnetic resonance (MR) imaging, was compared with a known blood pool agent, Gd-DTPA-polylysine, in an animal model. The relative signal intensities of liver, renal cortex, pancreas, and trunk muscle were assessed in 12 pigs between 4 seconds and 120 minutes after injection of a 20 μmol/kg dose of each contrast agent, by using a FLASH (fast low-angle shot) sequence. Except for muscle, all tissues showed visible enhancement after injection of either contrast agent. After injection of Gd-DTPA-polymer, enhancement patterns in the liver, renal cortex, and pancreas were similar to those seen after injection of Gd-DTPA-polylysine. No statistically significant differences in enhancement between the two contrast agents were found at any time point. The authors conclude that the contrast kinetics of Gd-DTPA-cascade-polymer are similar to those of Gd-DTPA-polylysine and that this agent may also be used as a blood pool contrast agent for MR imaging. |
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Keywords: | Contrast enhancement Contrast media Contrast media blood pool Contrast media experimental Gadolinium |
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