| 一种结构新颖的肟醚类化合物的合成及其生物活性研究 |
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| 引用本文： | 吐松,徐龙鹤,于春睿,张弘,李志念.一种结构新颖的肟醚类化合物的合成及其生物活性研究[J].有机化学,2007,26(2):228-234. |
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| 作者姓名： | 吐松 徐龙鹤 于春睿 张弘 李志念 |
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| 作者单位： | 1. 大连理工大学精细化工国家重点实验室,大连,116012
2. 沈阳化工研究院,沈阳,110021 |
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| 基金项目： | 致谢 本论文实验经费由沈阳博美达化学有限公司提供,生物活性测定工作由沈阳化工研究院农药生物测定中心完成,特此致谢. |
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| 摘 要： | 以苯并五元环为基本结构对肟醚类strobilurin杀菌剂侧链进行修饰, 共设计合成了13个结构新颖的肟醚类化合物. 室内生物活性测试结果表明所合成的化合物对小麦白粉病(Eryiphe graminis)和黄瓜霜霉病(Pseudoperonospora cubensis)均具有优异的抑菌活性, 而所合成的部分茚取代肟醚类化合物还具有广谱的杀虫活性. 同时, 用钯催化“一锅法”反应以较高的收率合成了关键中间体2-乙酰基茚衍生物.
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| 关 键 词： | 肟醚 strobilurin 抑菌活性 钯催化 2-乙酰基茚 |
| 收稿时间： | 2006-4-24 |
| 修稿时间： | 2006-04-24 |
Synthesis and Biological Activities of Novel Oxime Ethers |
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| TU Song,XU Long-He,YU Chun-Rui,ZHANG Hong,LI Zhi-Nian.Synthesis and Biological Activities of Novel Oxime Ethers[J].Chinese Journal of Organic Chemistry,2007,26(2):228-234. |
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| Authors: | TU Song XU Long-He YU Chun-Rui ZHANG Hong LI Zhi-Nian |
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| Affiliation: | 1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012;2. Shenyang Research Institute of Chemical Industry, Shenyang 110021 |
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| Abstract: | Thirteen novel oxime ethers were designed and synthesized by modifying the side chain of oxime ether strobilurin fungicide with a benzopentatomic ring as the essential structure. Biological activity testing on these compounds showed that they all had good fungicidal activities against Eryiphe graminis and Pseudoperonospora cubensis. Indene-substituted compounds also had insecticidal activities. The key inter- mediate 2-acetylindene compounds were synthesized by one-pot palladium-catalyzed reaction in good yields. |
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| Keywords: | strobilurin |
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