| 组织工程化软骨修复软骨损伤 |
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| 引用本文： | 侯俊华. 组织工程化软骨修复软骨损伤[J]. 中国组织工程研究与临床康复, 2012, 16(28): 5269-5276 |
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| 作者姓名： | 侯俊华 |
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| 作者单位： | 天津市中医药研究院附属医院,天津市,300120 |
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| 摘 要： | 背景:目前临床上多采用自体或异体软骨移植、软骨膜或骨膜移植、软骨细胞移植等方法进行软骨损伤修复,但均因取材局限、免疫排斥等导致效果不佳。利用组织工程的方法再造软骨,为软骨缺损的临床修复提供了新的思路与途径。目的:利用SCI数据库文献检索和深度分析功能,对于组织工程软骨的文献资料趋势进行多层次探讨分析,根据检索文献结果分析组织工程软骨的发展趋势。方法:通过计算机检索SCI数据库中2001/2010有关组织工程软骨的文献,检索词为"软骨(cartilage);组织工程(tissueengineering);软骨细胞(chondrocyte/cartilage cell);软骨组织(cartilage tissue);支架材料(scaffold materials);种子细胞(seed cell)",以文字和图表的形式进行统计和结果分析,描述其分布特征。结果与结论:SCI数据库2001-01/2010-12收录组织工程软骨相关文献总计3137篇,中国在该领域的文献产出量逐渐增多,总体呈上升趋势,Biomaterials《生物材料》杂志发表文献量最多。美国在该领域文献产出量多于其他国家,对该领域研究起到重要作用,发表文献较多的机构集中在美国的哈佛大学,莱斯大学,麻省理工学院,哥伦比亚大学,加利福尼亚大学圣地亚哥分校等。
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| 关 键 词： | 软骨 组织工程 软骨细胞 软骨组织 支架材料 种子细胞 文献计量 |
Tissue-engineered cartilage for treatment of cartilage defects |
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| Hou Jun-hua. Tissue-engineered cartilage for treatment of cartilage defects[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2012, 16(28): 5269-5276 |
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| Authors: | Hou Jun-hua |
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| Affiliation: | Hou Jun-hua Affiliated Hospital,Tianjin Academy of Traditional Chinese Medicine,Tianjin 300120,China |
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| Abstract: | BACKGROUND:Autologous or allogenic cartilage transplantation,transplantation of cartilage or periosteum,cartilage cell transplantation are applied in repairing cartilage injuries,but all the material limitations of immune rejection lead to ineffective results.Tissue-engineered cartilage provides a new idea and method for the clinical repair of cartilage defects.OBJECTIVE:To analyze the literatures on the tissue-engineered cartilage for treatment of cartilage defects through SCI database and to understand the development tendency of the tissue-engineered cartilage.METHODS:A retrieval was performed for the literature addressing the tissue-engineered cartilage for treatment of cartilage defects,using |
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| Keywords: | of " cartilage tissue engineering chondrocyte/cartilage cell cartilage tissue scaffold materials seed cell" in SCI database(2001-01/2010-12).The retrieval results were analyzed and the trends were described in words and graphics. RESULTS AND CONCLUSION 137 papers about tissue-engineered cartilage for treatment of cartilage defects published between 2001-01 and 2010-12 were retrieved in SCI database and most of papers were published as original articles.The overall number of literature had an upward trend from 2001 to 2010.Biomaterials published most papers in this field.United States published more literature than other countries and play important roles in the field of the tissue-engineered cartilage for treatment of cartilage defects.Most of papers were published from Harvard University Rice University Massachusetts Institute of Technology Columbia University University of California San Diego.This paper provides a valuable reference for researchers to understand the overview and present situation of this field. |
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