毛细管色谱法测定盐酸米多君中的有机溶剂残留量

目的建立毛细管气相色谱法测定盐酸米多君中的有机溶剂残留量。方法用HP-FFAP毛细管气相色谱柱,FID检测器,以正丙醇为内标进行测定。结果乙醇、乙腈、乙酸的线性范围分别为20～800μg.L-1(r=0.999 9)、1.64～65.6μg.L-1(r=0.999 7)、20～800μg.L-1(r=0.999 5),平均回收率分别为100.2%、99.7%、99.6%,RSD分别为0.74%、1.17%、1.37%(n=9)。结论本方法简单、准确、灵敏度高、重现性好,适用于盐酸米多君中有机溶剂残留量的测定。

Determination of residual organic solvents in midodrine hydrochloride by capillary gas chromatography

Objective To develop a gas chromatography method for the determination of residual organic solvents in midodrine hydrochloride.Methods The samples were injected into HP-FFAP capillary column and analyzed with FID detector using n-propanol as the internal standard.Results The linear ranges of ethanol,acetonitrile and acetic acid were 20-800 μg · L-1(r=0.999 9),1.64-65.6 μg · L-1(r=0.999 7),20-800 μg · L-1(r=0.999 5),respectively;the recoveries were 100.2%,99.7% and 99.6% with RSD of 0.74%,1.17% and 1.37%(n=9),respectively.Conclusions The method is simple,accurate and sensitive with good reproducibility.It can be used for the determination of the residual organic solvents in midodrine hydrochloride.