Applications of proteomics in pharmaceutical research and development |
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| Affiliation: | 1. Advanced Medical Research Center, Yokohama City University, Fukuura 3-9, Kanazawa, Yokohama 236-0004, Japan;2. Graduate School of Medical Life Science, Yokohama City University, Fukuura 3-9, Kanazawa, Yokohama 236-0004, Japan;3. Graduate School of Medicine, Yokohama City University, Fukuura 3-9, Kanazawa, Yokohama 236-0004, Japan;1. Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine;2. Disease Biomarker Analysis and Molecular Regulation, St. Marianna University Graduate School of Medicine;1. Dipartimento di Scienze della Vita e dell''Ambiente, Università Politecnica delle Marche, Ancona, Italy;2. Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden;3. Department of Food, Environmental and Nutritional Sciences, Università degli Studi di Milano, Milan, Italy;1. Department of Applied Tumor Pathology, Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan;2. Department of Respiratory Medicine, School of Medicine, Kitasato University, Kanagawa, Japan;3. Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kitasato University, Kanagawa, Japan;4. Department of Pathology, School of Medicine, Kitasato University, Kanagawa, Japan;1. Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan;2. Graduate School of Science and Engineering, Saitama University, Shimo-Okubo 255, Sakura-ku, Saitama 338-8570, Japan |
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| Abstract: | The significance of proteomics in the pharmaceutical industry has increased since overcoming initial difficulties. This review discusses recent proteomics publications from pharmaceutical companies to identify new trends in proteomics applications to research and development. Applications of proteomics such as chemical proteomics, protein expression profiling, targeted protein quantitation, analysis of protein-protein interactions and post-translational modification are widely used by various sections of the industry. Technological advancements in proteomics will further accelerate pharmaceutical research and development. |
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