蚓激酶胶囊对急性脑梗死患者脑循环动力学影响的临床研究

目的观察和研究蚓激酶胶囊治疗急性脑梗死患者的疗效及对脑循环动力学的影响。方法采用随机、双盲和平行对照的方法，把82例患者分为对照组40例与蚓激酶胶囊组42例，同样接受脑梗死的基本治疗，而蚓激酶胶囊组加用蚓激酶胶囊。对2组治疗前、治疗后的脑神经功能缺损评分、脑循环动力学参数（CVDI）等进行对比。结果①神经功能缺损评分，蚓激酶胶囊组治疗前（10．85±3．26）与治疗后（5．04±1．89）相比，差异有统计学意义（P〈0．01）；对照组治疗前（10．62±3．28）与治疗后（6．12±1．76）相比，差异有统计学意义（P〈0．01）；蚓激酶胶囊组治疗有效率（90．50％）与对照组（77．5％）相比，差异有统计学意义（P〈0．05）。②蚓激酶胶囊组病灶一侧CVDI中，脑血流量及血流速度治疗后（4．26±1．26）ml／s；（9．98±1．82）cm／s]较治疗前（4．13±1．46）ml／s；（7．12±1．63）cm／s]显著增加（P〈0．05），较对照组治疗后（4．62±1．26）ml／s；（9．26±1．58）em／s]亦有显著增加（P〈0．05）。脑血管外周阻力及临界压力蚓激酶胶囊组和对照组治疗后（1826±258）Pa．s／m1；（6．02±1．84）kPa；（1926±253）Pa．s／ml；（7．03±1．43）kPa]较治疗前（2132±323Pa．s／ml），（7．26±1．68）kPa；（2058±278）Pa．s／ml，（7．84±1．36）kPa]明显降低（P〈0．05）。结论蚓激酶胶囊治疗急性脑梗死患者疗效好，能明显改善脑血流灌注，降低脑循环阻力，减少神经功能缺损，从而达到治疗脑梗死的目的，作为脑梗死的治疗药物安全有效。

Clinical research of lumbrukinase capsule on cerebral hemodynamics in patients with acute infarction

Objective To observe and study the clinical efficacy of lumbrukinase capsule and its effect on cerebra hemodynamics in patients with acute infarction. Methods Totally 88 patients were enrolled. This clinical trial was randomly double-blind and parallel controlled. The patients with acute infarction were divided into two groups. All patients recieved same basic treatment; The treatment goup trented by oral administration of lumbruki-nase capsule then scoring the condition of neural functional deficits before and after the treatment; meanwhile the ce-rebrovascular dynamics index (CVDI) of the patients were measured. Results ①The neural functional deficits of patients in trial group tended to be repaired. The effective rate( ER) was 90. 5% ,but the control group's ER was 77.5%. ②The total cerebral blood flow and velocityin the focal side of brain after the treatment in the treatment group showed a statistically significant increase,compared with those before the treatment(P<0.05),and even with the co up(P<0.05). And the cerebral vascular resistance(R) and critical pressure showned a statistically significant decrease(P<0.05). Conclusions These results reveal that the lumbrukinase capsule is effective in re-lieving the neural functional deficits of patients with acute infarction by reducing cerebral circulation's resistance. It is a safe and effective drug treating cerebral infarction.