| A CLINICAL STUDY ON PROSTATE CANCER DIAGNOSIS WITH cDNA MACROARRAY |
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| 作者姓名： | 钟惟德 刘良式 刘文华 江福能 曾广翘 戴奇山 何慧婵 毕学成 彭志强 谢克基 魏鸿霭 |
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| 作者单位： | [1]DepartmentofUrology,theFirstMunicipalPeople＇sHospital,GuangzhouMedicalCollege,Guangzhou510180 [2]InstituteforLifeSciences,SunYat-SenUniversity,Guangzhou510060 |
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| 摘 要： | Objective: To diagnose prostatic cancer (CAP) with cDNA macroarray. Methods: Total RNA was isolated from patients with prostate cancer and from normal people, and poly(A) RNA was further purified. Then differentially expressed genes were analysed in CaP and normal prostate by cDNA macroarray system. Results: There were differential expressions of nine prostate-associated specific genes in CaP as compared with normal prostate, among which, 7 were significantly up-regulated and 2 were down-regulated. Conclusion: As a diagnostic approach at molecular level, the cDNA macroarray is supposed to elevate the detection rate of CaP.
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| 关 键 词： | 前列腺肿瘤 cDNA 诊断方法 分子机制 CaP |
| 收稿时间： | 12 October 2004 |
| 修稿时间： | 17 January 2005 |
A clinical study on prostate cancer diagnosis with cDNA macroarray |
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| Wei-de Zhong,Liang-shi Liu,Wen-hua Liu,Fu-neng Jiang,Guang-qiao Zeng,Qi-shan Dai,Hui-chan He,Xue-cheng Bi,Zhi-qiang Peng,Ke-ji Xie,Hong-ai Wei.A CLINICAL STUDY ON PROSTATE CANCER DIAGNOSIS WITH cDNA MACROARRAY[J].Chinese Journal of Cancer Research,2005,17(1):66-70. |
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| Authors: | Wei-de Zhong Liang-shi Liu Wen-hua Liu Fu-neng Jiang Guang-qiao Zeng Qi-shan Dai Hui-chan He Xue-cheng Bi Zhi-qiang Peng Ke-ji Xie Hong-ai Wei |
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| Affiliation: | (1) Department of Urology, the First Municipal People’s Hospital, Guangzhou Medical College, 510180 Guangzhou;(2) Institute for Life Sciences, Sun Yat-Sen University, 510060 Guangzhou |
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| Abstract: | Objective: To diagnose prostatic cancer (CaP) with cDNA macroarray. Methods: Total RNA was isolated from patients with prostate cancer and from normal people, and poly(A) RNA was further purified. Then differentially expressed genes were analysed in CaP and normal prostate by cDNA macroarray system. Results: There were differential expressions of nine prostate-associated specific genes in CaP as compared with normal prostate, among which, 7 were significantly up-regulated and 2 were down-regulated. Conclusion: As a diagnostic approach at molecular level, the cDNA macroarray is supposed to elevate the detection rate of CaP. |
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| Keywords: | Prostate Neoplasm cDNA macroarray |
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