| 噪声对大鼠学习记忆及海马胆碱能系统的影响 |
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| 引用本文： | 汤艳,李祥,王丽.噪声对大鼠学习记忆及海马胆碱能系统的影响[J].工业卫生与职业病,2010(1). |
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| 作者姓名： | 汤艳 李祥 王丽 |
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| 作者单位： | 泸州医学院; |
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| 基金项目： | 四川省卫生厅基金项目(070228) |
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| 摘 要： | 目的观察噪声对大鼠学习记忆及海马胆碱能系统的影响。方法将24只Wistar大鼠,随机分为噪声组和对照组,噪声组在80 dB(A)白噪声下持续暴露30 d,用大鼠穿梭箱测试大鼠的学习记忆能力,化学比色法检测海马乙酰胆碱转移酶(ChAT)和胆碱酯酶(AChE)的活力,受体放射配基结合实验测定海马M型受体的结合性。结果噪声组大鼠主动回避反应次数明显减少、主动和被动回避反应潜伏期明显延长,与对照组比较,差异有统计学意义(P0.05)。噪声组大鼠海马ChAT活力明显降低、AChE活力明显升高,与对照组比较,差异有统计学意义(P0.01)。此外,噪声组大鼠海马M型受体最大结合容量较对照组明显降低,差异有统计学意义(P0.05)。结论噪声暴露能影响大鼠海马胆碱能系统,降低学习记忆能力。
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| 关 键 词： | 噪声 学习记忆 海马 胆碱能系统 |
The Influence of Noise on Learning and Memory in Rats and Cholinergic System in Hippocampus |
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| TANG Yan,LI Xiang,WANG Li.The Influence of Noise on Learning and Memory in Rats and Cholinergic System in Hippocampus[J].Industrial Health and Occupational Diseases,2010(1). |
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| Authors: | TANG Yan LI Xiang WANG Li |
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| Affiliation: | Luzhou University of Medical Science;Luzhou 646000 China |
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| Abstract: | Objective To observe the effect of noise exposure on learning and memory capability and cholinergic system in hippocampus of rat and to probe its possible mechanism.Methods 24 Wistar rats were randomly divided into noise group and control group.The noise group was exposed to 80dB(A)noise for one month.The learning and memory capability of rats was measured by means of shuttle box.The activity of acetyl-transferase(ChAT)and acetyl-choline-esterase(AChE)in the hippocampus of rats was detected by chemical colo... |
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| Keywords: | Noise Learning and memory Hippocampus Cholinergic system |
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