| 胰岛素脂质体的制备及在电致孔下的经皮渗透 |
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| 引用本文： | 戚明,蒋国强,丁富新.胰岛素脂质体的制备及在电致孔下的经皮渗透[J].中国医药工业杂志,2005,36(12):751-753. |
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| 作者姓名： | 戚明 蒋国强 丁富新 |
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| 作者单位： | 清华大学化工系,北京,100084 |
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| 摘 要： | 采用反相蒸发法制备了平均粒径122.7nm的胰岛素脂质体,并考察了电致孔经皮转运情况.结果表明,在电致孔条件下,胰岛素脂质体2h累积渗透量是载药脂质体被动扩散的1倍;是原药及其与空白脂质体混合物的2～3倍.
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| 关 键 词： | 胰岛素 脂质体 经皮给药 电致孔 |
| 文章编号： | 1001-8255（2005）12-0751-03 |
| 收稿时间： | 2004-07-19 |
| 修稿时间： | 2004年7月19日 |
Preparation and Transdermal Delivery by Electroporation of Insulin Liposomes |
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| Authors: | QI Ming JIANG Guo-Qiang Ding Fu-Xin |
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| Affiliation: | Dept. of Chemical Engineering, Tsinghua University, Beijing 100084 |
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| Abstract: | The insulin liposomes with average diameter of 122.7nm were prepared by reverse phase evaporationmethod. The transdermal delivery by electroporation of insulin liposomes was investigated. The results showed that underthe electroporation condition, the 2h accumulative penetration amount of insulin liposomes was double the amount ofpassive diffusion and 2 - 3-fold increase than the bulk and also the mixture of bulk and blank liposomes. |
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| Keywords: | insulin liposome transdermal drug delivery electroporation |
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