sCD30动态监测在移植肾急性排斥反应时的意义

摘要] 目的 探讨血清可溶性CD30（sCD30）水平在肾移植术后急性排斥反应（AR）的变化及意义。方法 采用酶联免疫吸附法对肾移植术后22例发生AR的患者及20例顺利恢复,无排斥反应的患者sCD30水平进行动态监测，观察比较两组患者sCD30的变化规律。结果 排斥反应组术后具有较高的sCD30水平，和无排斥反应组相比在术后第5d、第7d有统计学意义(P<0.05)。排斥反应组sCD30水平在糖皮质激素冲击治疗后下降，但耐糖皮质激素性排斥者的下降速度较糖皮质激素敏感性排斥者缓慢，冲击治疗后的sCD30差异具有显著性(P<0.05)。结论 sCD30水平变化可作为肾移植AR的诊断指标及判断排斥反应对糖皮质激素冲击治疗是否敏感。

Implication of monitioring soluble CD30 level in acute rejection of renal allograft

Abstract] Objective To study the significance of post-transplant soluble CD30 (sCD30) level in monitoring of acute rejection of renal allograft recipients.Methods sCD30 plasma levels were dynamically determined in 22 cases of rejection and 20 cases of no-rejection by an enzyme-linked immunosorbent assay .sCD30 plasma levels were compared in two groups.Results After transplantation, recipients with acute rejection showed higher relative levels of plasma sCD30 on days 5 and 7 compared with patients without rejection, the difference was significant (P<0.05). sCD30 plasma levels in rejection group decreased after intensive therapy of glucocorticoid ,but the decreased speed of steroid-resistant rejection was slower than steroid-sensitive rejection.there was a significant difference(P<0.05).Conclusions The change of sCD30 can served as a diagnostic index of rejection and predic the sensitivity of acute rejection to intensive therapy of glucocorticoid.