2-(5-取代苯氧甲基-1,3,4-噻二唑-2-亚胺基)-5-(取代苯基亚甲基)-4- 噻唑啉酮的合成

以2-氨基-5-取代苯氧甲基-1,3,4-噻二唑(1)为起始原料, 合成了中间体2-氯乙酰氨基-5-取代苯氧甲基-1,3,4-噻二唑)-2-乙酰亚胺(2)和2-(5-取代苯氧甲基-1,3,4-噻二唑-2-亚胺基)-4-噻唑啉酮(3), 化合物3进一步与取代苯甲醛发生类Knoevenagle缩合反应, 得到了一系列2-(5-取代苯氧甲基-1,3,4-噻二唑-2-亚胺基)-5-(取代苯基亚甲基)-4-噻唑啉酮类化合物4a～4p. 目标化合物4a～4p的结构经IR, ¹H NMR和元素分析确证.

Synthesis of 2-[5-(Substituted phenyloxy)methyl-1,3,4-thiadiazol-2- ylimino]-5-(substituted benzylidene)-4-thiazolidinones

A series of 2-5-(substituted phenyloxy)methyl-1,3,4-thiadiazol-2-ylimino]-5-(substituted ben-zylidene)-4-thiazolidinones (4a～4p) were synthesized by quasi-Knoevenagel condensation of 2-5-(substi- tuted phenyloxy)methyl-1,3,4-thiadiazol-2-ylimino]-4-thiazolidinones (3) with substituted benzaldehydes. The intermediates 3 and 2-chloroacetamido-5-(substituted phenyloxy)methyl-1,3,4-thiadiazoles (2) were prepared by using 2-amino-5-(substituted phenyloxy)methyl-1,3,4-thiadiazoles (1) as a starting material. The structures of 4a～4p were confirmed by IR, ¹H NMR spectra and elemental analyses.