| 自由基清除剂预防环磷酰胺致大鼠性腺损伤的实验研究 |
| |
| 引用本文： | 康国贵 郭仁寿. 自由基清除剂预防环磷酰胺致大鼠性腺损伤的实验研究[J]. 中华儿科杂志, 1995, 33(3): 164-164 |
| |
| 作者姓名： | 康国贵 郭仁寿 |
| |
| 作者单位： | 湖北省沙市第二人民医院儿科，湖北医科大学第二附属医院儿科 |
| |
| 摘 要： | 应用自由基清除剂维生素Ｅ、维生素Ｃ和别嘌呤醇预防环磷酰胺（ＣＴＸ）所致大鼠性腺损伤。结果显示，两性预防组大鼠血和性腺组织中的丙二醛（ＭＤＡ）及超氧化物歧化酶（ＳＯＤ）分别明显低于和高于ＣＴＸ组；电镜下，预防组大鼠睾丸精子细胞线粒体增多，空泡化明显轻于ＣＴＸ组；睾丸、附睾头体重量及精子数、睾丸日产精子数和大鼠产仔数，预防组均明显高于ＣＴＸ组，而胚胎吸收数则明显低于ＣＴＸ组。表明维生素Ｅ、维生素Ｃ和别嘌呤醇等自由基清除剂对ＣＴＸ所致的性腺损伤有一定的预防作用，在一定程度上能保护大鼠精子的发生和成熟，使其生殖功能维持在一定水平。
|
| 关 键 词： | 性腺，环磷酰胺，自由基清除剂 |
IMPACT OF FREE RADICAL SCAVENGERSON ALTERATIONS OF SERUM AND OVAR-IAN MALONDIALDEHYDE AND SUPEROX-IDE DISMUTASE ACTIVITY INDUCED BYCYTOXAN IN YOUNG FEMALE RATS |
| |
| KangGuogui,Guo Renshou,Chen Zhongyi,et al.. IMPACT OF FREE RADICAL SCAVENGERSON ALTERATIONS OF SERUM AND OVAR-IAN MALONDIALDEHYDE AND SUPEROX-IDE DISMUTASE ACTIVITY INDUCED BYCYTOXAN IN YOUNG FEMALE RATS[J]. Chinese journal of pediatrics, 1995, 33(3): 164-164 |
| |
| Authors: | KangGuogui Guo Renshou Chen Zhongyi et al. |
| |
| Abstract: | he impact of free radical scavengers,vitamin E(VE),vitamin C(VC)and allopurinol(AL)onchanges of serum and ovarian malondialdehyde(MDA )and superoxide dismutase(SOD)activity induced bycytoxan(CTX)was studied in young rats. The resultsshowed that the serum and ovarian MDA was lowerand SOD was higher in preventive group than in CTXgroup. This study suggests that VE,VC and AL havecertain preventive effects on the gonadal damage in-duced by CTX through effectively scavenging free radi-cals of blood and gonad in rats. |
| |
| Keywords: | Gonads Cyclophosphamide FreeRadical Scavengers |
| 本文献已被 CNKI 维普 等数据库收录！ |
