Thietanyl protection in the synthesis of 1-alkyl-8-bromo-3-methyl-3,7-dihydro-1<Emphasis Type="Italic">H</Emphasis>-purine-2,6-diones |
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Authors: | F A Khaliullin Yu V Shabalina R M Sharafutdinov |
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Affiliation: | 1.Bashkir State Medical University,Ufa,Russia |
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Abstract: | The protection of the 7-NH group in 8-bromo-3-methyl-3,7-dihydro-1H-pyrine-2,6-dione during the synthesis of 7-ubsubstituted 1-alkyl-8-bromo-3-methyl-3,7-dihydro-1H-pyrine-2,6-diones with a thienyl group was applied that was introduced by the reaction with 2-chloromethylthiirane. The thietanyl
protection was removed by treating with sodium alcoholate after the oxidation with hydrogen peroxide to thietane 1,1-dioxide
group. |
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Keywords: | |
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