脂类及脂蛋白在胃肠道癌患者中的作用

目的：探讨脂质（甘油三酯、总胆固醇）和脂蛋白（高密度脂蛋白胆固醇、低密度脂蛋白胆固醇）在癌形成中的作用。方法：测定56例癌症患者和27例健康对照血清甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL-C）和脂质过氧化终末产物丙二醛（MDA，以此作为脂质过氧化程度标志）浓度。结果：癌症患者TG、TC、LDL-C明显高于对照组。P值均〈0．01，同时伴HDL-C（P=0．000）下降。但胃癌患者HDD-C（P=0．085）和结肠癌患者TG（P=0．655）与健康对照无差异。脂质过氧化产物MDA癌症组明显高于对照组（P=0．000），且各癌肿均比对照组高。结论：脂质和脂蛋白可能在癌症形成过程中起着重要作用。

Role of lipid and Upoprotein in gastrointestinal tract cancer patients

Objective:To study the role of lipid(triglyceride and total cholesterol) and lipoprotein(high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) in gastrointestinal tract cancer patients. Methods:The serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C) and lipid peroxidation end-product malondialdehyde(MDA,as a marker of lipid peroxidation degree) were measured in 56 gastrointestinal tract cancer patients and 27 healthy controls. Results:Compared to the healthy controls,the serum TC,TG and LDL-C in cancer group were higher(all P<0.01) while HDL-C decreased (P=0.000).Lipid peroxidation end-product MDA was found to be significantly elevated in all cancer patients compared with that in the healthy controls(P=0.000),but HDL-C in the gastric cancer patients(P=0.085) and TG in the colonic cancer patients(P=0.655) were no significant difference as the date were analysed by ANOVA. Conclusion:The results suggest that lipid and/or lipoprotein may play important role in carcinogenesis.