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| Sansalvamide A固相合成新方法 | |
| 引用本文： | 刘守信,冯霄,耿艳楼,姚军,李军章.Sansalvamide A固相合成新方法[J].有机化学,2005,25(5):604-607. |
| 作者姓名： | 刘守信 冯霄 耿艳楼 姚军 李军章 |
| 作者单位： | 1. 西安交通大学环境与化学工程学院,西安,710049;河北科技大学化学与制药工程学院,石家庄,050018 2. 西安交通大学环境与化学工程学院,西安,710049 3. 河北科技大学化学与制药工程学院,石家庄,050018 |
| 摘 要： | 报道了Pd催化丁基二乙基硅烷树脂与N-Boc-4-溴代苯丙氨酸甲酯直接反应形成Si—Ar键一步构建出硅基连接分子的新方法, 并采用Boc策略增长肽链, 以PyBOP (benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluoro- phosphate)为环合剂固相合成了sansalvamide A. |
| 关 键 词： | 固相合成 硅基连接分子 Pd催化剂 环肽类 sansalvamide A |
| 收稿时间： | 2004-7-12 |
| 修稿时间： | 2004年7月12日 |
Novel Solid-phase Synthetic Method of Sansalvamide A |
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| LIU Shou-Xin,FENG Xiao,GENG Yan-Lou,YAO Jun,LI Jun-Zhang.Novel Solid-phase Synthetic Method of Sansalvamide A[J].Chinese Journal of Organic Chemistry,2005,25(5):604-607. | |
| Authors: | LIU Shou-Xin FENG Xiao GENG Yan-Lou YAO Jun LI Jun-Zhang |
| Affiliation: | (College of Environment and Chemical Engineering, Xi'an Jiaotong University, Xi'an 710049) (College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018) |
| Abstract: | It was reported that butyldiethylsilane polystyrene reacted with N-Boc-4-bromophenylalanine under palladium catalyzation to directly form silicon-linker with silicon aryl carbon bond. The peptide chain was elongated by using Boc strategy. And sansalvamide A was obtained by solid phase synthesis using Py- BOP (benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate) as cyclization reagent. |
| Keywords: | sansalvamide A |
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