周剂量多西紫杉醇、奥沙利铂联合5-氟尿嘧啶／亚叶酸钙治疗晚期胃癌疗效观察

目的：观察周剂量多西紫杉醇、奥沙利铂联合5-氟尿嘧啶／亚叶酸钙治疗晚期胃癌的近期疗效，毒副作用及生活质量改善情况。方法：18例晚期胃癌患者以多西紫杉醇25mg／m^2d1、d8、d15静脉滴注1小时，奥沙利铂65mg／m2d1、d8静脉滴注3小时，亚叶酸钙100mgd～d5静脉滴注2小时，5-氟尿嘧啶500mg／m^2 d1—d5静脉滴注4小时。4周为1个周期，2周期为1个疗程。所有病人至少接受2周期以上。客观疗效（CR＋PR）和毒副作用按WHO进行评价，生活质量按临床受益反应（cBR）进行评价。结果：18例均可评价疗效，完全缓解（CR）0例，部分缓解（PR）10例，总有效率55．6％，临床受益反应有效率72％，中位唧5．6月。主要毒副反应为骨髓抑制，消化道反应和神经毒性，大部分为Ⅰ～Ⅱ级，可以耐受。结论：每周低剂量多西紫杉醇、奥沙利铂联合5-氟尿嘧啶／亚叶酸钙治疗晚期胃癌近期疗效好，毒副反应轻，耐受性好，病人生活质量明显改善。

Weekly administration of docetaxel and oxaliplatin combined with 5 - FU ＋ LV for advanced gastric,cancer

Objective ：To observe the short term curative effect, toxicity and quality of life with weekly administration of docetaxel and oxaliplatin combined 5 - FU ＋ LV for advanced gastric cancer. Motheds ： Eighteen cases with advanced gastric cancer were observed. Docetaxel 25mg/m2 iv for 3h, dl, d8, d15. oxaliplatin 65mg/m2 iv for 3h. dl ,d8. LV 100mg iv for 2h d1 - d5. 5 - FU 500mg/m2 iv for 4h, d1- d5 and repeated every 28 days. To evaluate CR ＋ PR and toxicity refer to WHO standard, quality of life. Results： Total response rate was 55.6%. Clinical ben- efit effect rate was 72%. Median TIP was 5.6 months. Myelosuppresion, toxicity of digestive tract and nerve were Ⅰ - Ⅱgrade and tolerable. Conclusion ： Patients treated with the low - dose weekly administration of docetaxel and oxaliplatin combined 5 - FU ＋ LV for advanced gastric cancer had a superior response rate. Quality of life is improved obviously.