瑞舒伐他汀与阿托伐他汀治疗老年高脂血症患者临床疗效的比较

目的探讨瑞舒伐他汀治疗老年高脂血症患者的疗效和安全性,并与阿托伐他汀进行比较。方法选择2012年6¹2月在我院门诊干部诊疗科就诊的老年患者128例,随机分为瑞舒伐他汀组64例(瑞舒伐他汀5mg/d)和阿托伐他汀组64例(阿托伐他汀10mg/d),共治疗8周。2组患者继续原发病的常规治疗,停用其他调脂药物2周,以减少对疗效判断的干扰。结果治疗8周后,瑞舒伐他汀组TC、TG和LDL-C下降幅度分别为25.9%、13.5%和33.7%,阿托伐他汀组下降幅度分别为22.6%、12.1%和31.4%,2组下降幅度比较,差异无统计学意义(P>0.05)。瑞舒伐他汀组与阿托伐他汀组HDL-C上升幅度差异有统计学意义(9.7%vs 3.2%,P<0.05)。2组患者对药物的依从性好,无药物不良反应。结论瑞舒伐他汀5mg与阿托伐他汀10mg在降低TC、TG及LDL-C方面相似;瑞舒伐他汀可提高HDL-C水平,且在老年患者中两者安全性相同。

Curative effect of rosuvastatin and atorvastatin in elderly hyperlipoidemia patients

Objective To compare the efficacy and safety of rosuvastatin and atorvastatin in elderly hyperlipoidemia patients.Methods One hundred and twenty-eight elderly phyperlipoidemia patients who visited our department from from May 2012to December 2012were randomly divided into rosuvastatin treatment group(n=64)and atorvastatin treatment group(n=64).Patients in rosuvastatin treatment group were treated with rosuvastatin(5mg/d)and those in atorvastatin treatment group were treated with atorvastatin(10mg/d)for 8weeks.Primary hyperlipoidemia received conventional therapy with anti-hyperlipoidemia drugs withdrawn for 2weeks in order to accurately assess the curative effect of rosuvastatin and atorvastatin.Results No significant difference was found in serum levels of TC,LDL-C and TG,although they were lower in rosuvastatin treatment group than in atorvastatin treatment group after 8-week treatment(25.9% vs 22.6%,33.7%vs 31.4%,13.5%vs 12.1%,P>0.05).The serum HDL-C level was significantly higher in rosuvastatin treatment group than in atorvastatin treatment group(9.7%vs 3.2%,P< 0.05).The drug dependence was good in two groups with no adverse event.Conclusion The efficiency and safety of rosuvastatin(5mg/d)and atorvastatin(10mg/d)are similar in reducing the serum levels of TC,TG,LDL-C,and rosuvastatin can increase the serum HDL-C level in elderly hyperlipoidemia patients.