肿瘤转移抑制基因nm23在涎腺腺样囊性癌表达的研究

目的：探讨肿瘤转移抑制基因nm23与涎腺腺样囊性癌（salivary adenoid cystic carcinoma,SACC)预后的关系。方法：采用免疫组织化学链亲和素法分析52例SACC的nm23表达，并分析nm23与SACC病理学分型、临床分期、局部复发、远处转移和患者生存率的关系。结果：nm23表达与SACC病理学分型、临床分期、局部复发和患者生存率无明显相关（P＞0．05），而与远处转移呈高度负相关关系（P＜0．01）。结论：nm23能抑制SACC远处转移的发生，并可作为预后指标来预测SACC的远处转移，指导临床治疗。

The expression of nm23 in salivary adenoid cystic carcinoma

Objective．To investigate the relationship between nm23 and the prognosis of patients with salivary adenoid cystic carci noma (SACC).Methods．The immunoactivity of nm23 of 52 cases with SACC was determined by immunohistochemistry method (Streptavidin-Biotin method).The relationship between nm23 and the histological type,clinical stage,local recurrence,distant metastasis of the tumor and survival rate of the patients with SACC were analysed.Results．Statistical analysis showed that the expression levels of nm23 were correlated inversely with distant metastasis potential (P＜0.01),and had no significant relation with histo logical type,clinical stage,local recurrence and survival rate (P＞0.05).Conclusion．The nm23 has a suppressive effect on distant metastasis of SACC and the evaluation of nm23 can act as a predictor of distant metastasis of SACC to direct the clinical treatment.