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| 几丁糖万古霉素缓释放系统的制备 | |
| 引用本文： | 陶杰,王文伟,丁星,丁浩,谢匡诚,吴小峰,张明贵,陆元善. 几丁糖万古霉素缓释放系统的制备[J]. 中国矫形外科杂志, 2002, 9(7): 694-695 |
| 作者姓名： | 陶杰 王文伟 丁星 丁浩 谢匡诚 吴小峰 张明贵 陆元善 |
| 作者单位： | 1. 上海第一人民医院骨科,上海市武进路85号,200080 2. 复旦大学基础医学院生理教研室 3. 上海第一人民医院检验科微生物室 4. 上海市第一人民医院中心实验室 |
| 摘 要： | 目的：研制几丁糖万古霉素缓释放系统。方法：几丁糖作为药物缓释载体是一种良好生物相容性的氨基多糖，通过分子间交联，溶剂蒸发，和模具分隔技术，制成药物的缓释放系统。同时测定几丁糖万古霉素DDS的抑菌作用。结果：制备的几丁糖万古霉素DDS有效抑制金黄色葡萄球菌和大肠樾 菌10d。结论：几丁糖与万古霉素能有效结合，并能缓慢释放万古霉素，体外达到较持久的抑菌作用。 |
| 关 键 词： | 几丁糖 万古霉素 缓释放系统 骨感染 |
| 文章编号： | 1005-8478(2002)07-0694-02 |
| 修稿时间： | 2002-02-07 |
The Preparation of the Chitosan Plate Loaded Vancocin as a Drug Sustained Delivery System |
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| TAO Jie,WANG Wen wei,DING Xing,et al.. The Preparation of the Chitosan Plate Loaded Vancocin as a Drug Sustained Delivery System[J]. The Orthopedic Journal of China, 2002, 9(7): 694-695 | |
| Authors: | TAO Jie WANG Wen wei DING Xing et al. |
| Affiliation: | TAO Jie,WANG Wen wei,DING Xing,et al.Orthopedic Department,the 1st People's Hospital,Shanghai 20080 |
| Abstract: | Objective:To prepare the chitosan plate loaded vancocin as a Drug Sustained Delivery System(DSDS).Methods:Chitosan has proven to be a biocompatible aminopolysaccharide and a adjuvant for controlled release of pharmaceuticals.Combined cross linking,solvent evaporation,and a model cutting technique were used to prepare the chitosan plate as the DSDS of vancocin;meanwhile,antibacterial activities of vancocin released from the DSDS were detected.Result:The DSDS of the chitosan loaded vancocin effectively inhabited the two common causative organisms of Staphylococcus and Escherichia coli as long as 10 days in vitro.Conclusion:Chitosan is sufficiently combined with vancocin,and gradually releases it,which inhabits the organisms of Staphylococcus and Escherichia coli in vitro. |
| Keywords: | Chitosan Vancocin Drug Delivery Sustained System(DSDS) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
