| 谷胱甘肽S-转肽酶基因多态性与动脉粥样硬化发病机制的研究 |
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| 引用本文： | 唐建金,王连生. 谷胱甘肽S-转肽酶基因多态性与动脉粥样硬化发病机制的研究[J]. 国际遗传学杂志, 2008, 32(1): 225-229. DOI: 10.3760/cma.j.issn.1673-4386.2009.03.015 |
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| 作者姓名： | 唐建金 王连生 |
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| 作者单位： | 南京医科大学第一附属医院心脏科,210029; |
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| 摘 要： | 既往研究已表明谷胱甘肽S-转肽酶(GSTs)存在基因多态性,这种突变可增加人体对癌源性物质及炎症性疾病的敏感性.近年的研究结果提示GSTs基因多态性与动脉粥样硬化密切相关,这种相关性使我们从分子水平上探讨动脉粥样硬化的发病机制,从而达到基于个体基因型采取预防及治疗措施.
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| 关 键 词： | 谷胱甘肽S-转肽酶基因多态性 动脉粥样硬化 基因-环境交互作用 |
Advances on the Study of Glutathione S-Transferase Genetic Polymorphisms in Atherosclerosis Disease |
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| TANG Jian-jin,WANG Lian-sheng. Advances on the Study of Glutathione S-Transferase Genetic Polymorphisms in Atherosclerosis Disease[J]. International JOurnal of Genetics, 2008, 32(1): 225-229. DOI: 10.3760/cma.j.issn.1673-4386.2009.03.015 |
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| Authors: | TANG Jian-jin WANG Lian-sheng |
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| Abstract: | Glutathione S-transferase gene exhibits genetic polymorphisms, and this variation can in-crease the susceptibility to carcinogenesis and inflammatory disease. Recent research suggests the gene polymor-phism of ghitathione S-transferase is associated with atherosclerosis. The study of this relationship and consider-ation of the molecular aspects of the causes of atherosclerosis should lead to new approaches to the prevention and clinical treatment of atherosclerosis according to individual genotypes. |
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| Keywords: | Glutathione S-transferase gene polymorphismsAtherosclerosisGene-environment in-teraction |
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