梅毒患者1355例的血清学诊断和疗效判断的临床研究

目的：探讨梅毒患者的血清学诊断和疗效判断。方法：采用梅毒螺旋体凝集试验和快速血浆反应素环状卡片试验（rapid plasma regain test，RPR）对1257例梅毒和98例妊娠梅毒患者进行测试。在苄星青霉素治疗后，1257例梅毒患者使用RPR随访了24个月。98例妊娠梅毒患者中，66例妊娠梅毒患者治疗组和32例未干预对照组进行了新生儿存活率和先天性梅毒儿发病率比较。结果：在1257例梅毒患者青霉素治疗24个月后，455例一期梅毒患者转阴数为387例（85.05％），589例二期梅毒患者和213例潜伏期患者转阴数分别为539例（91.51％）和102例（47.89％），一期和二期梅毒患者的转阴数和转阴率之间比较差异无统计学意义（P＞0.05），一期和二期与潜伏期梅毒患者之间比较差异有统计学意义（均P＜0.05）。98例妊娠梅毒中，66例妊娠梅毒治疗组新生儿存活63例（95.45%），较之32例未干预对照组13例（40.63%）明显增高（P〈0.05）；66例妊娠梅毒治疗组先天性梅毒发生率为13例（19.70%），较之32例未干预组为22例（68.75%）明显降低（P〈0.05）。结论：梅毒患者应早发现，早治疗。苄星青霉素是治疗梅毒的首选药物，妊娠梅毒患者苄星青霉素治疗后可以提高新生儿存活率和降低先天梅毒儿的发生率。

The clinical study of serology diagnosis and curative effect test in 1 355 patients with syphilis

Objectiv e： To explore the clinical study of serology diagnosis and curative effect test in 1 355 patients with syphilis. Methods：The 1 257 paients with syphilis and 98 patients with pregnancy syphilis were confirmed diagnosis with tre-ponema pallidum particle agglutination test（TPPA） and rapid plasma regain test（RPR）. After Benzatihine Benzylpenicilin thera-py, the 1 257 patients with syphilis were followed 24 months by RPR. In 98 patients with pregnancy syphilis, the neonates live rate of the 66 patients with pregnancy syphilis therapy section and 32 pectients with no-interference controls was done compared study;the incidence rate of congenital syphilis infant of the 66 patients with pregnancy syphilis therapy section and the 32 patients with no-interference controls done compared study also. Results： In 1 257 cases confirmed diagnosis general syphilis and after penicillin therapy 12 months, the trans-negative counts（and rate） of the 455 patients with primary syphilis was 387 case（85.05%）, but the 589 patients with secondary syphilis and the 213 patients with latent syphilis were 539 cas-es（91.51%） and 102 cases（47.89%） respectively. The trans-negative counts（and rate） of 455 patients with primary syphilis was no significantly difference than those in the 589 patients with secondary syphilis（P〉0.05）, but the primary and secondary syphilis were significantly higer than those in the 213 patients with latent syphilis（all P〈0.05）. In 98 patients with pregnan-cy syphilis the neonates live rate（95.45%） in 66 patients with pregnancy syphilis therapy section was significantly higher those in 32 patients with no-interference controls （ 40 . 63%） （ P〈0 . 05 ） . The congential syphilis incidence rate in 66 patients with pregnancy syphilis therapy section （19.70%） was significantly lower than those in 32 patients with no-interference con-trols（68.75%）（P〈0.05）. Conclusion： The syphilis patients should be early-find, early-diagnosis and early-therapy. The Ben-zathine Benzylpenicilin remain the therapy of first choice drug, but may be raised the neonates live rate and decreased con-gential syphilis incidence rate for pregnancy syphilis.