口腔鳞状细胞癌中分化抑制因子-1的表达及其与微血管生成的关系 |
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引用本文: | 郝晓鸣,;杨大江,;王晓毅,;梁新华.口腔鳞状细胞癌中分化抑制因子-1的表达及其与微血管生成的关系[J].口腔医学研究,2014(8):757-759. |
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作者姓名: | 郝晓鸣 ;杨大江 ;王晓毅 ;梁新华 |
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作者单位: | [1]深圳市蛇口人民医院口腔科,广东深圳518000; [2]深圳市西丽人民医院口腔科;,广东深圳518000; [3]四川大学华西口腔医院头颈肿瘤外科;,广东深圳518000; [4]四川大学口腔疾病研究国家重点实验室,广东深圳518000; |
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摘 要: | 目的:探讨口腔鳞状细胞癌(Oral squamous cell carcinoma,OSCC)中分化抑制因子-1(inhibitor of differentiation-1,Id-1)的表达及其与临床病理学特征和肿瘤微血管生成的关系。方法:应用免疫组织化学SP法检测65例OSCC中Id-1,CD34表达,并计数微血管密度(microvessel density,MVD)。结果:Id-1定位于肿瘤细胞胞质,65例OSCC中有49例Id-1呈(75.38﹪)阳性表达,其与OSCC分化程度,淋巴结转移和TNM分期密切相关(P〈0.01),而与患者性别及肿瘤发生部位无关;Id-1的表达与MVD值显著相关(P〈0.01)。结论:Id-1的高表达可能在OSCC分化和淋巴结转移过程中起重要作用,并与肿瘤微血管生成有关。
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关 键 词: | 口腔鳞状细胞癌 分化抑制因子-1 血管生成 免疫组化 |
Correlation between Inhibitor of Differentiation- 1 Expression and Angiogenesis in Oral Squamous Cell Carcinoma |
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Affiliation: | HAO Xiao-ruing, YANG Da-jiang, WANG Xiao- yi, et al. Department of Stomatology, Shekou People's Hospital of Shenzhen , Shenzhen 518000 |
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Abstract: | Objective: To investigate the correlation between inhibitor of differentiation-1 ptotein expression and clinicopathologic characteristics in oral squamous cell carcinoma(OSCC). Methods: Id-1 protein epression in 65 cases of OSCC was detected by immunohistochemical staining. Microvessel density(MVD) in OSCC was measured. Results: Id-1 protein was mainly detected in cytoplasm in OSCC cell. Id-1 positive expression occurred in 49 out of the 65 tumor samples (75.38 %). The differentiation degree of OSCC ,lymph node metastasis and UICC TMN classification were closely correlated with Id-1 positive expression(P〈0.01). But there was no significant eorelation between the positive expression and sex,tumor location. Id-1 expression was positively correlated with MVD in OSCC(P〈0.01). Conclusion: Id-1 positive expression in OSCC may play a potential role in the differentiation, lymph node metastasis and the angiogenesis of OSCC. |
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