| N5,10-亚甲基四氢叶酸还原酶基因多态性与颅内动脉瘤的关系 |
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| 引用本文： | 邓维意,孙卫文,戴文伟,许绍强,伍建伟,李明昌,何伟文,陆永健,陈盛强. N5,10-亚甲基四氢叶酸还原酶基因多态性与颅内动脉瘤的关系[J]. 河南预防医学杂志, 2011, 22(2): 89-91 |
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| 作者姓名： | 邓维意 孙卫文 戴文伟 许绍强 伍建伟 李明昌 何伟文 陆永健 陈盛强 |
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| 作者单位： | 1. 广州医学院,第二附属医院,广东,广州,510120
2. 广州三九脑科医院,广东,广州,510120 |
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| 摘 要： | 目的 探讨同型半胱氨酸和N<'5,10>-亚甲基四氢叶酸还原酶(MTHFR)基因多态性与颅内动脉瘤的关系.方法 运用多聚酶链反应技术检测76例颅内动脉瘤及77例正常人MTHFR基因多态性.结果 颅内动脉瘤组的MTHFR C677T CT基因型频率较正常对照高(P<0.01),患颅内动脉瘤的风险是对照组的2.57倍,两组...
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| 关 键 词： | 同型半胱氨酸 颅内动脉瘤 N5,10-亚甲基四氢叶酸还原酶 多态性 |
The relationship of polymorphism of methylenetetrahydrofolate reductase gene and Intracranial aneurysm |
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| DENG Wei-yi,SUN Wei-wen,DAI Wen-wei,XU Shao-qiang,CHEN Sheng-qiang,et al.. The relationship of polymorphism of methylenetetrahydrofolate reductase gene and Intracranial aneurysm[J]. Henan Journal of Preventive Medicine, 2011, 22(2): 89-91 |
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| Authors: | DENG Wei-yi SUN Wei-wen DAI Wen-wei XU Shao-qiang CHEN Sheng-qiang et al. |
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| Affiliation: | DENG Wei-yi,SUN Wei-wen,DAI Wen-wei,XU Shao-qiang,CHEN Sheng-qiang,et al.Institute of Neuroscience of Guangzhou,Guangzhou,Medical College Guangzhou 510120 China. |
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| Abstract: | Objective To explore relationship of polymorphism of methylenetetrahydrofolate reductase gene(MTHFR)with Intracranial aneurysm.Method The genotyes of MTHFR were determined by PCR-based assay in 76 patients with Intracranial aneurysm and 77 healthy controls.Results There were siganificant differences in the CT genotype frequenceies of methylenetetrahydrofolate reductase mutations between the patients and central groups(P<0.01).Conclusions methylenetetrahydrofolate reductase CT genotype may be independent ris... |
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| Keywords: | Homocysteine methylenetetrahydrofolate reductase Intracranial aneurysm Polymorphism |
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