| 2,6-二氯-3-氟吡啶合成新方法 |
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| 引用本文： | 杨维清,林羿成,王小宁.2,6-二氯-3-氟吡啶合成新方法[J].化工时刊,2014(8):4-7. |
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| 作者姓名： | 杨维清 林羿成 王小宁 |
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| 作者单位： | 西华大学物理与化学学院,四川 成都,610039 |
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| 基金项目： | 四川省教育厅自然科学重点项目，西华大学重点基金项目(Z1223322)。 |
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| 摘 要： | 以2,6-二氯吡啶为起始原料,经过硝化反应得到中间体2,6-二氯-3-硝基吡啶。2,6-二氯-3-硝基吡啶经过催化氢化还原反应得到中间体2,6-二氯-3-氨基吡啶,最后2,6-二氯-3-氨基吡啶重氮化反应得到2,6-二氯-3-氟吡啶,3步反应总收率69.3%。对合成目标化合物进行了质谱、核磁表征,结果表明结构正确。详细讨论了硝酸浓度、催化剂种类及用量、亚硝酸钠物质的量比等因素对反应的影响。该路线具有收率高、选择性好、工业化应用前景广等优点。
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| 关 键 词： | 2 6-二氯吡啶 2 6-二氯-3-硝基吡啶 2 6-二氯-3-氨基吡啶 2 6-二氯-3-氟吡啶 |
New Synthesis Method of 2,6-Dichloro-3-Fluoropyridine |
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| Yang Weiqing,Lin Yicheng,Wang Xiaonin.New Synthesis Method of 2,6-Dichloro-3-Fluoropyridine[J].Chemical Industry Times,2014(8):4-7. |
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| Authors: | Yang Weiqing Lin Yicheng Wang Xiaonin |
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| Affiliation: | Yang Weiqing,Lin Yicheng,Wang Xiaonin (Institute of Physics and Chemistry ,Xihua University,Siehuan Chengdu 610039) |
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| Abstract: | 2,6-Dichloro-3-nitropyridine was synthesized from 2,6-dichloropyridine. Then 2,6-dichloro-pyridin-3-amine was synthesized from 2,6-dichloro-3-nitropyridine by the catalytic hydrogenation reaction. At last, 2,6-dichloro-3-fluoropyridine was synthesized from 2,6-dichloropyridin-3-amine by the Diazo reaction. Overall yield of three steps reaction was 69. 3%. The target compound 2,6 -dichloropyridin-3 -amine was con-firmed by MS and NMR. The factors such as nitric acid concentration, the type and amount of catalyst, the molar rati-o of sodium nitrite were discussed in detail. This synthesis Strategy has high yield, high selectivity, better prospect of industrialization. |
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| Keywords: | 2 6-dichloropyridine 2 6-dichloro-3-nitropyridine 2 6-dichloropyridin-3-amine 2 6-dichloro-3-fluoropyridine |
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